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How Do Animals Re-Grow Limbs (And Why Can't We?)

Video vocabulary

immature

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US / ˌɪməˈtjʊə(r) /

UK / ˌɪməˈtʃʊr /

B1
  • adjecitve
  • Behaving like a child, especially emotionally
  • Not fully grown or developed

leg

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US / leɡ /

UK / lɛɡ /

A1
  • noun
  • Part of the body from the hips down
  • The piece of furniture that touches the ground

why

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US / waɪ /

UK / hwaɪ, waɪ /

A1
  • adverb
  • Question word to ask for a reason
  • exclamation
  • (Used to express surprise or approval)

joint

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US / dʒɔɪnt /

UK / dʒɔɪnt /

A2
  • adjecitve
  • Shared; involving working together; in common
  • noun
  • Body parts where bones meet and can move together
  • Point at which two things meet (e.g. a road)
  • A club or restaurant; place where you are

much

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US / mʌtʃ /

UK / mʌtʃ /

A1
  • adjecitve
  • Very; to a high level or degree
  • adverb
  • A lot; large amount; a high degree of
  • Nearly; basically
  • On many occasions; often
  • noun
  • A large amount; a great quantity

grow

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US / ɡrəʊ /

UK / ɡro /

A1
  • verb
  • To get bigger and more mature; make plants do this
  • To improve; to develop better skills over time
  • To develop and become bigger or taller over time

time

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US / taɪm /

UK / taɪm /

A1
  • noun
  • Speed at which music is played; tempo
  • Point as shown on a clock, e.g. 3 p.m
  • Number of hours, minutes needed to do something
  • Occasion when something happens
  • Period or occasion that something occurred
  • Period in history or the past
  • Something measured in minutes, hours, days, etc.
  • How long an event takes; duration
  • verb
  • To check speed at which music is performed
  • To choose a specific moment to do something
  • To measure how long an event takes, e.g. a race
  • To schedule something to occur at a specific moment

board

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US / bɔ:d /

UK / bɔrd, bord /

A1
  • noun
  • Surface for posting or showing information
  • Group of persons who direct an organization
  • Long piece of material used for riding the waves
  • Long thin piece of wood, used for building; plank
  • verb
  • To enter a ship, plane, or other vehicle
  • To cover with long wooden strips of wood
  • To pay money to live in someone's house; lodge

responsible

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US / rɪ'spɒnsəbl /

UK / rɪˈspɑnsəbəl /

A2
  • adjecitve
  • Being the cause of something that has occurred
  • Having the duty of dealing with something
  • Able to be trusted to do what needs to be done

animal

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US / ˈænɪml /

UK / ˈænəməl /

A1
  • noun
  • A living creature that is not a plant or person

start

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US / stɑ:t /

UK / stɑrt /

A1
  • noun
  • First time or place that a thing exists; beginning
  • First opportunity to achieve something, e.g. a job
  • Sudden action or movement because you are scared
  • other
  • Beginning of something in place or time
  • verb
  • To do, be or happen for the first time; begin
  • To turn something on

limb

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US / lɪm /

UK / lɪm /

B1
  • noun
  • Leg, arm, branch or wing
  • Part of something that extends out over an area

math

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US / mæθ /

UK / mæθ /

A2
  • noun
  • Study or science of numbers and shapes

just

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US / dʒʌst /

UK / dʒʌst /

A1
  • adjecitve
  • Proper or appropriate; as is deserved
  • Doing or being what is right or fair
  • Legally correct; having enough evidence
  • adverb
  • Almost; nearly
  • Exactly at the time of
  • Exactly (the same as, like)

for

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US / fə(r) /

UK / fɔr,fə /

A1
  • preposition
  • Used to show the purpose, or need of something

capability

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US / ˌkeɪpəˈbɪləti /

UK / ˌkeɪpə'bɪləti /

B1
  • noun
  • Means, ability, or potential to do something

regeneration

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US / rɪˌdʒenə'reɪʃn /

UK / rɪˌdʒɛnəˈreʃən /

B2
  • noun
  • Act of adding more life or energy into

moniker

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US / ˈmɒnɪkə(r) /

UK / ˈmɑ:nɪkə(r) /

A1
  • noun
  • Familiar name for a person (often a shortened version of a person's given name)

those

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US / ðəʊz /

UK / ðoz /

A1
  • determiner
  • The people or things we are talking about
  • pronoun
  • The objects far from the speaker

begin

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US / bɪ'ɡɪn /

UK / ˈbeɡɪn /

A1
  • verb
  • To do the first part of an action; to start

epidermis

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US / ˌepɪˈdɜ:mɪs /

UK / ˌepɪˈdɜ:rmɪs /

A1
  • noun
  • Outer layer of the skin

revert

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US / rɪˈvɜ:t /

UK / rɪˈvɜ:rt /

B1
  • verb
  • To return to the original owner again

benefit

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US / 'benɪfɪt /

UK / ˈbɛnəfɪt /

A2
  • noun
  • Good result or effect, something advantageous
  • verb
  • To have a good effect or be helpful

awesome

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US / 'ɔ:səm /

UK / ˈɔsəm /

B2
  • adjecitve
  • Great; wonderful; stupendous

mass

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US / mæs /

UK / mæs /

B1
  • noun
  • Religious ceremony in some Christian churches
  • Large amount or number of something
  • Main or largest part of something
  • Large number of people considered as a whole
  • Amount of matter that an object has
  • verb
  • To gather people or things into a large group

soon

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US / su:n /

UK / sun /

A1
  • adverb
  • At a time not long from now

immediate

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US / ɪˈmi:diət /

UK / ɪˈmidiɪt /

A2
  • adjecitve
  • Being the very next to or just after
  • Done without delay; straight away

sort

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US / sɔ:t /

UK / sɔrt /

A1
  • noun
  • Group or class of similar things or people
  • verb
  • To organize things by putting them into groups
  • To deal with things in an organized way

terrific

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US / təˈrɪfɪk /

UK / təˈrɪfɪk /

B1
  • adjecitve
  • Spoken excellent; wonderful

lose

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US / lu:z /

UK / luz /

A1
  • verb
  • To be unable to keep in check or control something
  • To decrease in value or quantity (e.g. weight)
  • To stop having certain qualities or abilities
  • To stop having or being entitled to
  • To fail to win something that is being contested
  • To be unable to find something you once had
  • To be dependent on someone (used with 'not')

mammal

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US / 'mæml /

UK / ˈmæməl /

B1
  • noun
  • Animal which drinks milk from its mother

here

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US / hɪə(r) /

UK / hɪr /

A1
  • adverb
  • In this place; at this location, position or time

true

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US / tru: /

UK / tru: /

A1
  • adjecitve
  • Agreeing with the facts; not false; real or actual

will

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US / wɪl /

UK / wɪl /

A1
  • noun
  • Desire or choice of someone
  • Document saying who gets your money when you die
  • Strong desire to do something; determination
  • Desire to do something; strong wish to do
  • other
  • Used with verbs to express the future
  • verb
  • To leave property to someone after your death
  • To use mental effort to make something happen
  • Am (is, are) likely to do
  • To influence someone to do something
  • To make something happen by strongly wanting it

gene

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US / dʒi:n /

UK / dʒin /

B1
  • noun
  • Part of cell controlling development of a thing

consider

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US / kən'sɪdə(r) /

UK / kənˈsɪdər /

A1
  • verb
  • To think carefully about something

small

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US / smɔ:l /

UK / smɔl /

A1
  • adjecitve
  • Little in size; not big
  • (Of letters) not written in capital letters
  • Being insignificant or minor
  • (Of a business) with few people or things; local
  • (Of voice) being soft and quiet
  • (Of a child) being young

should

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US / ʃʊd /

UK / ʃʊd /

A1
  • other
  • Used to indicate what is proper or reasonable

while

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US / waɪl /

UK / hwaɪl, waɪl /

A1
  • conjunction
  • In spite of the fact that; although
  • During the time that; at the same time
  • noun
  • Short amount of time

shiny

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US / ˈʃaɪni /

UK / ˈʃaɪni /

A2
  • adjecitve
  • Reflecting a lot of light; bright and smooth
  • Bright because of producing light

tail

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US / teɪl /

UK / tel /

A2
  • noun
  • Extended part at the back of an animal's body
  • Back or last part of something e.g. shirt
  • verb
  • To be end of (a march or parade, line)
  • To follow someone secretly and watch what they do

basic

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US / 'beɪsɪk /

UK / ˈbesɪk /

A1
  • adjecitve
  • At the most important or easiest (beginner) level

stem

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US / stem /

UK / stɛm /

B1
  • noun
  • Long thin central part of a plant, bearing leaves
  • Long thin part supporting something e.g. a light
  • Main part of a word, e.g. 'use' in 'useful'
  • verb
  • To remove the stem of a flower or fruit
  • To start from or be the origin of
  • To stop something bad from spreading or developing

new

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US / nju: /

UK / nu, nju /

A1
  • adjecitve
  • Not old, recently born, built or made
  • Being or doing something for the first time
  • Not felt, seen or known previously
  • Having been recently bought or obtained

truth

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US / tru:θ /

UK / truθ /

A2
  • noun
  • Real facts about something

use

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US / ju:s /

UK / ju:s /

A1
  • noun
  • Ability to employ something
  • Need to enable it to work
  • Permission to do something with something
  • Act of spending money
  • Operation of a machine for its function
  • verb
  • To have; to eat, drink, consume etc.
  • To need to operate or work
  • To operate a machine, e.g. a computer
  • To treat a person badly
  • To do something with, for a task or purpose

eat

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US / i:t /

UK / it /

A1
  • verb
  • To put food in your mouth

certain

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US / ˈsə:tn /

UK / ˈsɚtn /

A1
  • adjecitve
  • Definite, fixed
  • Referring to an unspecified amount or quantity
  • Being sure about something; without doubt

after

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US / 'ɑ:ftə(r) /

UK / ˈæftɚ /

A1
  • adverb
  • Later than another time, or behind something
  • conjunction
  • Following something before
  • preposition
  • When an event happened or time has passed

connective

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US / kəˈnektɪv /

UK / kəˈnɛktɪv /

A2
  • adjecitve
  • Connecting or tending to connect

memory

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US / 'memərɪ /

UK / ˈmɛməri /

A2
  • noun
  • Ability of the mind to call back past things
  • Space for the storage of information on a computer
  • Something that has been remembered

day

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US / deɪ /

UK / de /

A1
  • noun
  • A period of 24 hours beginning at midnight
  • The period of time when it is light outside
  • Person's name

puzzle

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US / 'pʌzl /

UK / ˈpʌzəl /

A2
  • noun
  • Something challenging to explain or understand
  • Game requiring the player to find an answer
  • Game with many pieces, e.g. forming a picture
  • A problem requiring thought and skill to be solved
  • verb
  • To be a challenge to understand; confuse

actually

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US / ˈæktʃuəli /

UK / ˈæktʃuəli /

A1
  • adverb
  • Used to add new (often different) information

position

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US / pəˈzɪʃn /

UK / pəˈzɪʃən /

A1
  • noun
  • Person's opinion or attitude about something
  • Specific location where someone or something is
  • Where you play or your role on a sports team
  • Person's job or status level
  • Set of conditions affecting what you can (not) do
  • verb
  • To put in a particular location or direction

plus

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US / plʌs /

UK / plʌs /

A2
  • noun
  • A benefit or advantage
  • preposition
  • In addition; add
  • In addition to; Indicates a number above
  • Having a value greater than zero

top

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US / tɒp /

UK / tɑp /

A1
  • adjecitve
  • Being good or great; excellent
  • Being the most in degree or quality
  • noun
  • Item of clothing covering shoulders to waist, hips
  • A cover or lid
  • Part (e.g. road) that is the furthest away
  • Highest or upper part or point of something
  • Best or highest status or position
  • Flat upper surface or edge of an object
  • Child's toy that spins on its point
  • Upper section or leaves of fruits and vegetables
  • Winning in a sport or contest
  • verb
  • To be higher or larger than a specific value
  • To arrive at the highest point of something
  • To put a cover or layer or over something
  • To kill; murder
  • To hold the highest position on a list
  • To be more important, successful or better than
  • To beat someone or win at a game

pretty

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US / 'prɪtɪ /

UK / ˈprɪti /

A1
  • adjecitve
  • Being attractive to the eye in a simple way
  • adverb
  • Very; to a great degree

paper

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US / ˈpeɪpə(r) /

UK / ˈpeɪpər /

A1
  • adjecitve
  • Not existing in reality, or done infrequently
  • Made from the material that we use to make books
  • noun
  • Academic writing or a talk on a specific topic
  • Written test
  • Newspaper
  • Pages of a book are made from this

way

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US / weɪ /

UK / we /

A1
  • adverb
  • Used to emphasize the amount of something
  • noun
  • Particular aspect of something being thought about
  • One of various choices that could be made
  • Particular existing condition or state
  • (Often long) distance or length of time
  • How something is done
  • Route to go to a place
  • Small street
  • Usual behavior, emotions or habits of someone

medicine

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US / ˈmedsn /

UK / ˈmɛdɪsɪn /

A2
  • noun
  • Something used in treating illness or pain
  • Science of preventing, treating, or curing disease

take

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US / teɪk /

UK / tek /

A1
  • noun
  • Filming of a single scene for TV or the movies
  • verb
  • To accept something that is offered
  • To use a method of traveling, e.g. a bus or train
  • To use a camera to make (a photo)
  • To pick up something and go away with it
  • To study a subject in school
  • To attempt to pass (an exam)
  • To require a certain amount of time, money, space

fast

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US / fɑ:st /

UK / fæst /

A1
  • adjecitve
  • In a way that is difficult to move or change
  • Moving or able to move quickly
  • Showing time that is later than the actual time
  • adverb
  • With a great deal of speed
  • noun
  • Period of time when a person chooses not to eat
  • verb
  • To refuse food for a long time

human

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US / 'hju:mən /

UK / ˈhjumən /

A1
  • adjecitve
  • Concerning or characteristic of people
  • noun
  • A person; a man, woman or child

their

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US / ðɛː /

UK / ðer /

A1
  • determiner
  • Belonging to them

space

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US / speɪs /

UK / spes /

A1
  • noun
  • Empty area kept for a specific reason, like a car
  • Empty area with nothing in it
  • Area in the sky where the stars are
  • Area between written words on a page
  • verb
  • To make a certain distance or time between

everyone

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US / ˈevriwʌn /

UK / ˈɛvriˌwʌn /

A1
  • pronoun
  • Every person; everybody

institute

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US / 'ɪnstɪtju:t /

UK / ˈɪnstɪˌtut, -ˌtjut /

A2
  • noun
  • Organization studying science, engineering etc.
  • verb
  • To start or commence doing, e.g. a business plan

possible

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US / ˈpɒsəbl /

UK / ˈpɑsəbəl /

A1
  • adjecitve
  • Being able or appropriate for a task or purpose
  • Having a chance of happening, or being true

thank

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US / θæŋk /

UK / θæŋk /

A1
  • verb
  • To tell someone you are grateful to them

all

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US / ɔ:l /

UK / ɔl /

A1
  • adverb
  • Completely; totally
  • determiner
  • Being every one of something
  • pronoun
  • 100% of something; the complete amount

hold

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US / həʊld /

UK / hold /

A1
  • noun
  • Section of a ship or plane used for storing things
  • Influence or power held over someone
  • Place of support for hands or feet when climbing
  • verb
  • To agree to keep something for someone
  • To have the capacity to support/contain something
  • To control an area and protect it from attack
  • To not allow someone to leave a place
  • To cause an event to happen at a place or time
  • To use hands or arms to carry or keep something
  • To have a specific quality or property
  • To keep an image, belief or feeling in your mind
  • To have or own something
  • To wait before being able to talk on the phone
  • To limit the movement of someone in a sport

heart

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US / hɑ:t /

UK / hɑrt /

A1
  • noun
  • A feeling of care for others; compassion
  • Courage, confidence, and emotional strength
  • Be cheerfully encouraging
  • Most essential, important, or central part
  • Referring to a promise or something important
  • State or feelings of affection or deep love
  • Core part of a vegetable, e.g. a lettuce
  • The part of the body that pumps blood
  • Place where emotions are believed to be felt
  • A shape that represents love

work

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US / wɜ:k /

UK / wɚk /

A1
  • adjecitve
  • Activity completed in order to make money
  • noun
  • The product of some artistic or literary endeavor
  • Everything created by an author, artist, musician
  • Activity you do in order to make money
  • Place of employment
  • Final product or result of a some labor or effort
  • verb
  • To bring into a specific state of success
  • To be functioning properly, e.g. a car
  • To do your job in your company or workplace
  • To make an effort to do something
  • To operate a machine or device

remove

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US / rɪˈmu:v /

UK / rɪˈmuv /

A1
  • verb
  • To get rid of something completely
  • To make someone leave his or her job or position
  • To move, erase or take away from a place
  • To take something off (e.g. clothing)

they

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US / ðeɪ /

UK / ðe /

A1
  • pronoun
  • Two or more people, animals, or things

scishow

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US / ə'lɜ:tnəs /

UK / ə'lɜ:tnəs /

A1

have

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US / həv /

UK / hæv /

A1
  • verb
  • To drink, smoke, eat or use something
  • To experience the effects of something
  • To organize an event, or join in an activity
  • To own, possess, or hold something
  • To cause to happen or produce a particular effect

end

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US / end /

UK / ɛnd /

A1
  • noun
  • The point where a process or activity stops
  • A point that marks the limit of something; finish
  • Goal or desired result
  • The tip, edge or limit of something
  • verb
  • To be the last part of something

muscle

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US / 'mʌsl /

UK / ˈmʌsəl /

A2
  • noun
  • Physical power
  • Body tissue that moves parts of the body
  • verb
  • To use or muscles of force to get what you want

cover

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US / 'kʌvə(r) /

UK / ˈkʌvɚ /

A1
  • noun
  • A different version of another song
  • Bed sheets; blankets
  • (Police or military) protection from attack
  • Amount of money to be paid in an insurance claim
  • Thing you put over something to close or hide it
  • Front and back part of a book or magazine
  • Shelter built to protect from the natural elements
  • verb
  • To record a different version of another song
  • To include as part of its area
  • To put something over something to hide it
  • To discuss a subject in a talk or meeting
  • To form a layer over something so it is hidden
  • To have sufficient funds to pay for something
  • To include something within an agreed limit
  • To report news on TV, radio or in a newspaper
  • (Police or military) to protect from attack
  • To travel a certain distance in a given time
  • To wrap something with something, such as a cloth

before

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US / bɪˈfɔ:(r) /

UK / bɪˈfɔr,-ˈfor /

A1
  • adverb
  • At a time earlier than the present; previously
  • conjunction
  • In advance of something happening
  • preposition
  • In front of someone or something

recreate

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US / ˌri:kriˈeɪt /

UK / ˌri:krɪ'eɪt /

B1
  • verb
  • To make a past situation exist again

with

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US / wɪð /

UK / wɪð, wɪθ /

A1
  • preposition
  • As an employee of a certain company
  • Against something or someone
  • By using something as a means
  • Due to; because of
  • Including
  • Possessing as a feature
  • Related to
  • (Of the manner/attitude by which you do something)
  • Used to express that people or things are together

macrophage

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US / ˈmækrəfeɪdʒ /

UK / ˈmækrəˌfedʒ /

A1
  • noun
  • Large white blood cell that eats cancer cells, etc.

recently

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US / ˈri:sntli /

UK / 'risṇtlɪ /

A1
  • adverb
  • Just a while ago; not long ago

scar

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US / skɑ:(r) /

UK / skɑr /

B1
  • noun
  • Long lasting emotional pain from a bad experience
  • A mark on something made by scratching it
  • verb
  • To cause long lasting emotional pain
  • To leave a mark on something by scratching it

fibrous

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US / 'faɪbrəs /

UK / ˈfaɪbrəs /

C2
  • adjecitve
  • Containing, having or resembling threads

know

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US / nəʊ /

UK / noʊ /

A1
  • verb
  • To be familiar with a person or place, thing
  • To feel sure or be convinced about something
  • To discover or be aware of something
  • To be able to distinguish
  • To have knowledge of things

lizard

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US / ˈlɪzəd /

UK / ˈlɪzərd /

B2
  • noun
  • Reptile with scales and a long body and tail

his

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US / hɪz /

UK / hɪz /

A1
  • pronoun
  • Something belonging to a male person

mature

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US / məˈtʃʊə(r) /

UK / məˈtʃʊr /

A2
  • adjecitve
  • Behaving like an adult
  • Being fully developed physically
  • verb
  • (Wine, cheese) To age to improve its taste

activate

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US / ˈæktɪveɪt /

UK / ˈæktəˌvet /

B1
  • verb
  • To cause to happen; cause a chemical reaction
  • To make something start working

specialized

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US / ˈspeʃəlaɪzd /

UK / ˈspɛʃəlˌaɪzd /

A2
  • verb
  • To focus on one area of a field or profession
  • To name something individually

could

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US / kəd /

UK / kʊd /

A1
  • other
  • Past form of 'can' to mean have ability
  • Used to ask for something politely, or to offer

decade

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US / ˈdekeɪd /

UK / ˈdɛkˌed, dɛˈked /

B1
  • noun
  • Period of 10 years

method

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US / 'meθəd /

UK / ˈmɛθəd /

A2
  • noun
  • (Organized and planned) way of doing something

tissue

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US / ˈtɪʃu: /

UK / ˈtɪʃu /

A2
  • noun
  • Substance formed by cells of living thing; flesh
  • Kind of thin, light paper used to pack objects
  • Thin soft paper for blowing the nose, etc.

appendage

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US / əˈpendɪdʒ /

UK / əˈpendɪdʒ /

B1
  • noun
  • Part attached to a larger thing, e.g. arm to body

like

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US / laɪk /

UK / laɪk /

A1
  • adjecitve
  • Being equal in status or kind to something else
  • Similar; the same
  • adverb
  • For example
  • preposition
  • Used as a filler; used to ad emphasis
  • In a way similar to the way something is done
  • Such as; for example
  • verb
  • To want to
  • To find something pleasing; to prefer something

president

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US / ˈprezɪdənt /

UK / ˈprɛzɪdənt,-ˌdɛnt /

A2
  • noun
  • Person in charge of a country, or organization

tell

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US / tel /

UK / tɛl /

A1
  • verb
  • To (strongly) advise a person to do something
  • To be able to guess
  • To say or communicate information to someone
  • To inform, but without speaking; indicate
  • To have a negative effect on someone
  • To order someone to do something; command
  • To recognize something based on certain signs
  • To report something to an authority
  • To explain something or teach someone something

even

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US / 'i:vn /

UK / ˈivən /

A1
  • adjecitve
  • Being equal in influence, power, possibility etc.
  • Being divided equally or fairly
  • (Of teams/contest) with similar chances of success
  • Smooth, level, or regular
  • Can be divided by 2; ending in 2, 4, 6, 8, or 0
  • At a regular, equally steady manner
  • Remaining steady and unchanging
  • adverb
  • (When this is surprising) as well; too
  • (Used to compare two things/stress the difference)
  • verb
  • To make something level; to flatten
  • To make something equal

salamander

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US / ˈsæləmændə(r) /

UK / ˈsæləˌmændɚ /

C1
  • noun
  • Amphibian resembling a lizard

place

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US / pleɪs /

UK / ples /

A1
  • noun
  • Particular location, area or region
  • verb
  • To put someone in a particular type of situation
  • To put something in a certain location or position

remarkable

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US / rɪˈmɑ:kəbl /

UK / rɪˈmɑrkəbəl /

A2
  • adjecitve
  • Interesting and unexpected, worthy of notice

during

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US / ˈdjʊərɪŋ /

UK / ˈdʊrɪŋ, ˈdjʊr- /

A1
  • preposition
  • At some point in the course of an event or thing

again

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US / ə'ɡen /

UK / əˈɡɛn /

A1
  • adverb
  • One more time, once more

dead

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US / ded /

UK / dɛd /

A1
  • adjecitve
  • Not alive
  • Being bored or not interested
  • Unable to operate because electricity etc. ran out
  • Being unable to feel, physically or emotionally
  • adverb
  • Completely; absolutely

mean

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US / mi:n /

UK / min /

A1
  • adjecitve
  • Being good at
  • Nasty; unkind
  • Not liking to spend money; cheap; stingy
  • noun
  • Average of a set of numbers
  • verb
  • To express a particular idea or thought
  • To intend to do something in particular
  • To have a particular meaning or value

embryonic

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US / ˌembriˈɒnɪk /

UK / ˌembriˈɑ:nɪk /

C1
  • adjecitve
  • Undeveloped, as if in an early stage
  • Concerning an embryo or embryos

dose

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US / dəʊs /

UK / doʊs /

B1
  • noun
  • An amount of medicine to be taken at any one time
  • verb
  • To give a certain amount of something to someone

understanding

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US / ˌʌndəˈstændɪŋ /

UK / ˌʌndərˈstændɪŋ /

A1
  • adjecitve
  • Being sympathetic
  • noun
  • When you get the meaning correctly; comprehension
  • Knowledge about something or someone
  • verb
  • To know the meaning of language, what someone says

undifferentiated

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US / ˌʌndɪfəˈrenʃieɪtɪd /

UK / ˌʌndɪfəˈrenʃieɪtɪd /

B1
  • adjecitve
  • Not seen as different or distinct

site

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US / saɪt /

UK / saɪt /

A2
  • noun
  • Place that is reserved for a particular activity
  • Location of building work
  • Location of something
  • Place where something of special interest happened
  • Website
  • verb
  • To place something in a particular position, area

number

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US / ˈnʌmbə(r) /

UK / ˈnʌmbɚ /

A1
  • noun
  • Symbols such as 1, 2, 56, 793
  • Particular song or dance performed during a show
  • Total quantity or amount of things
  • verb
  • To put numbers on things
  • To assign a sequence within a group, series, set
  • To claim to be part of a larger group, series, set

find

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US / faɪnd /

UK / faɪnd /

A1
  • noun
  • Object discovered by chance
  • Things that have been discovered from searching
  • verb
  • To become aware of something that is happening
  • To discover or meet by chance
  • To decide if someone is guilty of a crime, or not
  • To learn through study, research, or effort
  • To discover something by looking for it

superstar

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US / 'su:pəstɑ:(r) /

UK / ˈsjupɚˌstɑr /

C2
  • noun
  • Someone who is dazzlingly skilled in any field

right

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US / raɪt /

UK / raɪt /

A1
  • adjecitve
  • Correct or true
  • The south side of you looking at the rising sun
  • adverb
  • Exactly in a place or time
  • Being appropriate for a particular event
  • In a straight or direct manner
  • noun
  • Something you are legally or morally allowed to do
  • Ideal of what is just and good
  • Political view based on conservatism
  • verb
  • To fix something previously wrong or unjust
  • To make upright, as a boat that has turned over

what

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US / wɒt /

UK / hwɑt, hwʌt, wɔt, wʌt,hwət, wət /

A1
  • pronoun
  • Thing or things that; the same kind as
  • Used to emphasize something you are about to say
  • adjecitve
  • Used to refer to a particular amount, or number
  • Used to place emphasis on a particular quality
  • adverb
  • To a certain degree
  • determiner
  • Question words used for asking for information
  • exclamation
  • Used to express excitement, shock, or surprise
  • Used to ask people to repeat something they said

cell

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US / sel /

UK / sɛl /

A2
  • noun
  • Smallest unit of living things in biology
  • Group of people - often from a secret organization
  • Prisoner's room in a jail
  • Shortened form of 'cellphone'

get

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US / ɡet /

UK / ɡɛt /

A1
  • verb
  • To become affected by illness or disease
  • To begin to feel or understand an emotion or idea
  • To send or bring someone or something home, etc.
  • To go somewhere to obtain something
  • To (cause to) do a particular thing
  • To obtain, receive or be given something
  • To currently have
  • To prepare for use
  • To understand something being said or read

eventually

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US / ɪˈventʃuəli /

UK / ɪˈvɛntʃuəli /

A2
  • adverb
  • After a long time; after many attempts; in the end

that

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US / ðæt /

UK / ðæt, ðət /

A1
  • adjecitve
  • The person or thing being talked about
  • Used to identify something both the speakers know
  • adverb
  • Used to reinforce adjectives and adverbs
  • To such a degree
  • conjunction
  • Used to connect a noun clause
  • Used to introduce an adverbial clause
  • Used to introduce a noun clause
  • determiner
  • Used as a noun to refer to something
  • pronoun
  • Referring an object far away
  • Used to refer to the relative pronoun ‘which’

then

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US / ðen /

UK / ðɛn /

A1
  • adverb
  • A time that is not now
  • Following another thing in time or arrangement
  • Following on reasonably from what was just stated
  • At that time, not now

regenerate

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US / rɪˈdʒenəreɪt /

UK / rɪˈdʒɛnəˌret /

B2
  • verb
  • To form or create new things

first

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US / fɜ:st /

UK / fɚst /

A1
  • adjecitve
  • 1st; Coming before all others in time or place
  • noun
  • Something that has not happened before
  • Position of the winner of a competition

guy

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US / ɡaɪ /

UK / ɡaɪ /

A1
  • noun
  • Man; boy; any person

lot

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US / lɒt /

UK / lɑt /

A1
  • noun
  • What happens to a person in life from chance; fate
  • A group of people seen together
  • Item for sale at an auction
  • Small area of land used for a purpose e.g. parking

real

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US / rɪəl /

UK / ˈriəl, ril /

A1
  • adjecitve
  • Actually existing or happening, not imagined
  • Being important or special

help

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US / help /

UK / hɛlp /

A1
  • noun
  • Something given to enable a person to do something
  • Assistance given to someone in need
  • Someone who makes something easier or possible
  • verb
  • To act to enable a person to do something; assist
  • To make something better or less difficult

pinpoint

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US / ˈpɪnpɔɪnt /

UK / ˈpɪnˌpɔɪnt /

B2
  • adjecitve
  • Exact, as of accuracy
  • verb
  • To locate something exactly
  • To identify or explain exactly

attainable

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US / əˈteɪnəbl /

UK / əˈteɪnəbl /

B1
  • adjecitve
  • Able to be attained or accomplished

release

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US / rɪ'li:s /

UK / rɪ'li:s /

A2
  • noun
  • Act of freeing someone from a duty or burden
  • Introduction of a new product, film, book, etc.
  • Relief from sadness, suffering or trouble
  • Act of freeing from a jail, cage, prison, etc.
  • verb
  • To free someone from a responsibility or burden
  • To allow a film, music etc. to be sold/distributed
  • To allow to leave a jail, cage, etc.; let out
  • To let go of something you are holding

call

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US / kɔ:l /

UK / kɔl /

A1
  • noun
  • A order or request for action
  • The sound an animal makes, often when in danger
  • A correct prediction, e.g. a decision in a game
  • A short visit to a place or person
  • A decision by a referee or umpire in a game
  • verb
  • To make a request or order for action
  • (Animal) to make sounds to warn of danger
  • To announce the date of an election
  • To make a judgment about something
  • To give someone or something a name
  • To guess in advance the result or outcome
  • To visit a place or person for a short time
  • To phone someone
  • To speak, announce or shout in a loud voice

collagen

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US / ˈkɒlədʒən /

UK / ˈkɑlədʒən /

A1
  • noun
  • Type of protein that is often used in skin cream and in plastic surgery because it makes skin look y

flatworm

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US / ˈflætwɜ:m /

UK / ˈflætwɜ:rm /

C2
  • noun
  • Parasitic or free-living worms with a flat body

from

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US / frəm /

UK / frʌm, frɑm,frəm /

A1
  • preposition
  • Starting at a particular place, time or level

breath

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US / breθ /

UK / brɛθ /

A2
  • noun
  • Air you take in and out of your body

back

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US / bæk /

UK / bæk /

A1
  • adjecitve
  • Farthest from the front e.g. in a classroom
  • adverb
  • Have returned to a place you were before
  • noun
  • The part of a chair that the upper body leans upon
  • Location at the rear of something
  • The reverse of side something
  • Area on the rear of your body
  • verb
  • To bet money on something
  • To go backwards in a car
  • To support and encourage someone or some cause

starfish

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US / ˈstɑ:fɪʃ /

UK / ˈstɑ:rfɪʃ /

A1
  • noun
  • Sea creature with five arms

trigger

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US / 'trɪɡə(r) /

UK / ˈtrɪɡɚ /

B1
  • noun
  • Lever on a gun that you pull to fire
  • Device that starts a process
  • verb
  • To start a process off e.g. a memory

think

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US / θɪŋk /

UK / θɪŋk /

A1
  • verb
  • To have an idea about something without certainty
  • To have an idea, opinion or belief about something

any

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US / 'enɪ /

UK / ˈɛni /

A1
  • adjecitve
  • One, or some, no matter which
  • pronoun
  • One (thing) of many; some

pathogen

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US / ˈpæθədʒən /

UK / ˈpæθədʒən /

C1
  • noun
  • Any disease-producing agent

rather

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US / 'rɑ:ðə(r) /

UK / ˈræðɚ, ˈrɑðɚ /

A1
  • adverb
  • Somewhat; fairly; not that much

where

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US / hwɛə /

UK / hwɛr, wɛr /

A1
  • conjunction
  • At or in the place which
  • In whatever place
  • pronoun
  • Word you use to ask the location of something

reversion

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US / rɪˈvɜ:ʃn /

UK / rɪˈvɜ:rʒn /

C1
  • noun
  • Act of doing the opposite

slash

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US / slæʃ /

UK / slæʃ /

B2
  • noun
  • Line ( / ) used in writing
  • Long, deep cut, caused by a sharp object
  • verb
  • To cut violently with a sharp object
  • To decrease something by a large amount

until

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US / ənˈtɪl /

UK / ʌnˈtɪl /

A1
  • conjunction
  • Up to; to a time when something happens
  • preposition
  • Before (a specific time)

join

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US / dʒɔɪn /

UK / dʒɔɪn /

A1
  • verb
  • To bring something close to another, to become one
  • To become a member of
  • To participate in an activity with others

poor

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US / pʊə(r) /

UK / pʊr /

A1
  • adjecitve
  • Inferior; below the normal standard
  • Deserving of pity or sympathy
  • Without money; not rich

form

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US / fɔ:m /

UK / fɔrm /

A1
  • noun
  • Sports team or person's current winning record
  • Document you complete when making an application
  • Visible shape or style; type; kind
  • verb
  • To organize something such as a club or group
  • To develop; to come into a shape or substance
  • To make something into a particular shape

layer

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US / ˈleiə /

UK / ˈleɚ /

B1
  • noun
  • One of several sheets of a material or object
  • verb
  • To put things one on top of another

over

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US / 'əʊvə(r) /

UK / ˈovɚ /

A1
  • adverb
  • Finished; no longer happening
  • Towards the ground/away from a standing position
  • noun
  • A set of six consecutive balls bowled in cricket
  • other
  • Finished
  • preposition
  • Showing the relation when a thing is above another
  • On or covering something
  • Above or across something
  • More than you need
  • From one side to the other
  • In the direction of; toward

large

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US / lɑ:dʒ /

UK / lɑ:rdʒ /

A1
  • adjecitve
  • Big; of great size; broad, tall, wide, or fat

wave

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US / weɪv /

UK / wev /

A2
  • noun
  • Movement of sound, air or energy
  • Deep and strong emotion that is suddenly felt
  • Slightly curved shape in hair
  • Frequency of movement of objects together
  • Up and down movement of water in a lake or sea
  • Signal with your hand to say hello or goodbye
  • verb
  • To cause to move side to side or back and forth
  • To swing back and forth as a result of the wind
  • To move your hand or arm to say hello or goodbye

skin

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US / skɪn /

UK / skɪn /

A2
  • noun
  • Outer covering of an animal used for leather; hide
  • Outer covering of a fruit or vegetable
  • Outer layer of an animal or human
  • Outer part of an object, such as a plane
  • verb
  • To defeat someone easily and completely
  • To hurt yourself, accidentally cutting yourself
  • To remove the outer covering from an animal

reduce

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US / rɪ'dju:s /

UK / rɪˈdus, -ˈdjus /

A2
  • verb
  • To try to decrease, e.g. your weight if overweight
  • To boil a liquid until it has decreased in amount
  • To make something smaller in size, amount, level

and

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US / ənd /

UK / ənd, ən,ænd /

A1
  • conjunction
  • Used to refer to two or more things
  • Plus; in addition; on top of that
  • Used to introduce an action that follows another

out

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US / aʊt /

UK / aʊt /

A1
  • adverb
  • No longer stylish (e.g. fashion)
  • Away from home, business, or the usual place
  • In a direction/movement away from inside or center
  • noun
  • Act when a batter cannot continue playing
  • verb
  • To tell people a secret

come

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US / kʌm /

UK / kʌm /

A1
  • verb
  • To arrive at a place
  • (Of mail) to be delivered
  • To move toward someone; go with someone
  • To reach a certain point or state

chemical

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US / ˈkemɪkl /

UK / ˈkɛmɪkəl /

A2
  • adjecitve
  • Made of various elements
  • noun
  • Basic substance produced by mixing elements

matrix

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US / ˈmeɪtrɪks /

UK / ˈmetrɪks /

B1
  • noun
  • Rock that surrounds rare stones
  • Pattern of lines, spaces, or numbers
  • Set of conditions that a person/thing develops in

specific

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US / spəˈsɪfɪk /

UK / spɪˈsɪfɪk /

A2
  • adjecitve
  • Precise; particular; just about that thing
  • Concerning one particular thing or kind of thing

free

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US / fri: /

UK / fri /

A1
  • adjecitve
  • Living, happening without being controlled
  • Costing no money
  • Not working; not busy
  • verb
  • To release (e.g. bird) from a cage or prison

immune

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US / ɪˈmju:n /

UK / ɪˈmjoon /

B1
  • adjecitve
  • Having a special protection from, e.g. the law

researcher

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US / rɪ'sɜ:tʃə(r) /

UK / rɪˈsətʃɚ /

A2
  • noun
  • Someone who works to find new facts and ideas

suggest

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US / səˈdʒest /

UK / səɡˈdʒɛst, səˈdʒɛst /

A1
  • verb
  • To mention something that could be done; propose

colleague

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US / 'kɒli:ɡ /

UK / ˈkɑlˌiɡ /

A2
  • noun
  • Person you work or cooperate with

vital

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US / 'vaɪtl /

UK / 'vaɪtl /

B1
  • adjecitve
  • Needed to support life; essential
  • Full of life; energetic

state

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US / steɪt /

UK / stet /

A1
  • adjecitve
  • Concerning region within a country
  • noun
  • Region within a country, with its own government
  • Situation or condition something is in
  • verb
  • To say; declare as fact

goal

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US / ɡəʊl /

UK / ɡol /

A2
  • noun
  • Something you try to do or achieve; an aim
  • (Sports) net into which you put a ball to score
  • (Sports) act of scoring by putting a ball in a net

james

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US / dʒeimz /

UK / dʒemz /

A1
  • proper noun
  • The name of seven Stuart kings of Scotland.
  • The name of two kings of England, Ireland, and Scotland.

below

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US / bɪ'ləʊ /

UK / bɪˈlo /

A1
  • preposition
  • In a lower position, place, or level

the

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US / ðə /

UK / ðə /

A1
  • article
  • Used to refer to something already mentioned
  • Used to show there is only one of something
  • determiner
  • Used to describe all of a family

year

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US / jə: /

UK / jɪr /

A1
  • noun
  • Unit of time equal to 12 months or 365 or 366 days
  • Used to refer to the age of a person

heal

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US / hi:l /

UK / hi:l /

B1
  • verb
  • To recover from or forget a bad experience
  • To make or become healthy or well again

how

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US / haʊ /

UK / haʊ /

A1
  • adjecitve
  • To what degree? in what amount?
  • adverb
  • (Used to explain the way to do something)
  • exclamation
  • For what purpose or reason?
  • (Used to ask someone or something's condition)

regrow

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US / ri:greʊ /

UK / ri:greʊ /

B1
  • verb
  • To continue growth after an injury or interruption

one

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US / wʌn /

UK / wʌn /

A1
  • pronoun
  • You; we; people in general; someone
  • The thing or person previously referred to
  • adjecitve
  • Used to refer to people generally
  • Being a strong example of (something mentioned)
  • number
  • Number 1

complexity

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US / kəm'pleksətɪ /

UK / kəmˈplɛksɪti /

B1
  • noun
  • State of having many parts and not being simple

order

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US / 'ɔ:də(r) /

UK / ˈɔrdɚ /

A1
  • noun
  • Religious or social group, as of nuns
  • Instructions to others to do what you want
  • State in which things are neat and organized
  • What you ask to buy, e.g. food in restaurant
  • Social or political control of an area
  • verb
  • To put things in a sequence, e.g. a, b, c
  • To give instructions to others to do what you want
  • To ask for something you want to buy, e.g. a meal

other

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US / 'ʌðə(r) /

UK / ˈʌðər /

A1
  • adjecitve
  • A thing different from that mentioned
  • determiner
  • (Something) else; not the first (one)
  • pronoun
  • Being the one and only thing of that category

body

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US / ˈbɒd.i /

UK / ˈbɑdi /

A1
  • noun
  • An object distinct from other objects
  • A group of people involved in an activity together
  • Main part of something
  • A person's physical self

also

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US / 'ɔ:lsəʊ /

UK / ˈɔlso /

A1
  • adverb
  • In addition; too; in a similar way

ones

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US / wʌnz /

UK / wʌnz /

A1
  • number
  • Number 1, a single person or thing

regenerative

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US / rɪ'dʒenərətɪv /

UK / rɪˈdʒɛnəˌretɪv, -ərətɪv /

B2
  • adjecitve
  • Of, relating to, or marked by regeneration

entire

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US / ɪn'taɪə(r) /

UK / ɛnˈtaɪr /

A2
  • adjecitve
  • Complete or full; with no part left out; whole

this

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US / ðɪs /

UK / ðɪs /

A1
  • adjecitve
  • Used to indicate something already been discussed
  • Used to indicate something happening around now
  • adverb
  • An indication by a physical motion or gesture
  • A specific amount of
  • determiner
  • Person, thing, or idea near you
  • pronoun
  • Person, thing that has already been discussed

level

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US / 'levl /

UK / ˈlɛvəl /

A2
  • adjecitve
  • (Sports) equal to another
  • Being steady and determined (e.g. a voice)
  • noun
  • Specific height of something
  • Amount of ability you have compared to others
  • Floor or deck within a building
  • Tool used to determine if something is lying flat
  • verb
  • To aim a gun at someone
  • To destroy a building; flatten an area completely
  • To make things flat or even
  • To make a score equal to another, in sports

instruction

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US / ɪn'strʌkʃn /

UK / ɪnˈstrʌkʃən /

A2
  • noun
  • A command for someone formally to do something
  • Act of teaching or explaining to others
  • Information about how to do or use something

arm

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US / ɑ:m /

UK / ɑrm /

A1
  • noun
  • Part of your body from your shoulder to your hand
  • A branch of another object e.g. company
  • The side part of a chair where your arms go
  • The influence or power an authority has
  • verb
  • To activate a weapon or bomb for use
  • To give a gun or other weapon to a person or group

little

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US / 'lɪtl /

UK / ˈlɪtl /

A1
  • adjecitve
  • Being short in length of time
  • Not great in size, amount, or degree; small
  • Being very young or younger than others
  • adverb
  • By an amount or degree that is not very much
  • Not often; rarely
  • noun
  • A person's name

you

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US / jʊ /

UK / ju /

A1
  • pronoun
  • Person someone is speaking or writing to
  • Person or people in general

might

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US / maɪt /

UK / maɪt /

A1
  • other
  • Used to politely request an action
  • Used to express that something could happen
  • Power, strength, force or influence

kind

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US / kaɪnd /

UK / kaɪnd /

A1
  • adjecitve
  • In a caring and helpful manner
  • friendly and considerate
  • noun
  • One type of thing

into

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US / 'ɪntə /

UK / ˈɪntu /

A1
  • preposition
  • Moving or going inside something
  • In the same direction as; in the direction of
  • So as to become; taking the state of

australian

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US / ɒˈstreɪliən /

UK / ɔˈstreljən /

A1
  • adjecitve
  • Concerning the culture and people of Australia
  • noun
  • People from Australia

make

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US / meɪk /

UK / mek /

A1
  • noun
  • Product made by a particular company; brand
  • verb
  • To arrange or prepare something e.g. dinner
  • To get to (a place) on time
  • To gain the status of (teacher, lawyer, etc.)
  • To create something by putting things together
  • To earn a certain amount of money at a job
  • To cause or force a person to do something
  • To cause something to happen or be formed

whole

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US / həul /

UK / hol /

A1
  • adjecitve
  • Complete or full; all of
  • Being in a good condition
  • noun
  • Complete amount or sum; total

bone

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US / bəʊn /

UK / bon /

A1
  • noun
  • Hard piece of your body that holds your muscles
  • verb
  • To remove bones from meat or fish

development

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US / dɪ'veləpmənt /

UK / dɪˈvɛləpmənt /

A2
  • noun
  • Act or process of growing bigger or more advanced
  • A new event related to a previous event

can

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US / kæn /

UK / kən,kæn /

A1
  • noun
  • A metal container for storing food
  • other
  • Able to; have the skill to; have the time to
  • verb
  • To have permission to
  • To be possible to do
  • To preserve food by sealing it in a metal container

protein

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US / ˈprəʊti:n /

UK / ˈprəʊˌtiːn /

B1
  • noun
  • Group of molecules made from amino acids

but

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US / bət /

UK / bʌt,bət /

A1
  • conjunction
  • Used before you say something different, opposite

subscribe

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US / səb'skraɪb /

UK / səbˈskraɪb /

B1
  • verb
  • To regularly pay to receive a service

foreleg

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US / ˈfɔ:leg /

UK / ˈfɔ:rleg /

C2
  • noun
  • Front foot of a four-legged animal

member

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US / ˈmembə(r) /

UK / ˈmɛmbɚ /

A1
  • noun
  • Part of the body of a human, animal
  • Person or thing belonging to a group or team

towards

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US / tə'wɔ:dz /

UK / 'təuədz, twɔ:dz /

A1
  • preposition
  • In the direction of someone or something

expect

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US / ɪk'spekt /

UK / ɪkˈspɛkt /

A1
  • verb
  • To believe something is probably going to happen

nerve

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US / nə:v /

UK / nɚv /

A2
  • noun
  • Fibers in the body that enable feeling, movement
  • Courage to do something that is difficult or risky

understand

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US / ˌʌndə'stænd /

UK / ˌʌndɚˈstænd /

A1
  • verb
  • To know the meaning of language, what someone says

stump

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US / stʌmp /

UK / stʌmp /

B2
  • noun
  • One of three standing part of a cricket wicket
  • The remaining part when the rest was cut off
  • verb
  • To campaign by making political speeches
  • To be too difficult for; baffle or perplex

cut

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US / kʌt /

UK / kʌt /

A1
  • noun
  • Act/instance of reducing the size or amount of
  • Small opening made using a sharp object, knife
  • A wound on someone's skin caused by a sharp object
  • verb
  • To reduce the size or amount of something
  • To use knife or scissors to divide, open surfaces

single

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US / 'sɪŋɡl /

UK / ˈsɪŋɡəl /

A1
  • adjecitve
  • Being one only, without others
  • Only; merely
  • Not married or in a relationship
  • noun
  • One run in cricket or a hit baseball
  • An individual song from a CD or album
  • Person who is not married or in a relationship

research

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US / rɪ'sɜ:tʃ /

UK / rɪˈsɚtʃ, ˈriˌsɚtʃ /

A2
  • noun
  • Study done to discover new ideas and facts
  • Work done to find or discover knowledge
  • verb
  • To study in order to discover new ideas and facts

transform

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US / træns'fɔ:m /

UK / trænsˈfɔrm /

C2
  • verb
  • To change the shape completely in a good way

repair

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US / rɪˈpeə(r) /

UK / rɪˈper /

A2
  • noun
  • How well cared for a thing is; physical condition
  • Action to fix or restore something that is broken
  • verb
  • To fix or restore something that is broken
  • To fix or correct the damage that one has caused

not

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US / nɒt /

UK / nɑt /

A1
  • adverb
  • Word indicating the negative
  • (Used to form the negative of verbs)

boom

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US / bu:m /

UK / bum /

B1
  • noun
  • Very fast increase in growth or popularity
  • A very loud and deep sound
  • verb
  • To experience a rapid increase in growth
  • To make a very loud and deep sound

liver

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US / ˈlɪvə(r) /

UK / ˈlɪvɚ /

B1
  • noun
  • Organ from animals served as food
  • Organ that absorbs food and cleans the blood

signal

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US / 'sɪɡnəl /

UK / ˈsɪɡnəl /

A2
  • adjecitve
  • Most important or most noticeable
  • noun
  • Movement of a hand or other means to send messages
  • Act/sound that tells people to do/start something
  • Road-side lights that direct traffic to go or stop
  • Sound and light waves carrying TV and radio data
  • verb
  • To be evidence/an indication something will happen
  • To make a noise or motion to tell someone to start

yet

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US / jet /

UK / jɛt /

A1
  • adverb
  • At a later time (used after ‘not’)
  • (Used to emphasize that thing is, will be greater)
  • Eventually; at a future time
  • Until now; up to the present
  • conjunction
  • Adding to what has been said, often as a contrast

would

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US / wʊd /

UK / wʊd /

A1
  • other
  • Used to indicate something imagined
  • Used to ask or request something politely
  • Verb used to indicate possibility, request etc.
  • Used to indicate a preference
  • Used to indicate a reaction
  • Indicates something that occurred repeatedly
  • Used to indicate willingness or ability to do

our

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US / 'aʊə(r) /

UK / aʊr /

A1
  • determiner
  • Belonging to us

wound

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US / waʊnd /

UK / waʊnd /

A2
  • noun
  • Sadness or displeasure caused by a bad memory
  • Physical injury, especially that suffered in war
  • verb
  • To rotate a part of say a watch to make it work
  • To hurt someone emotionally
  • To injure someone in a fight with a knife gun etc.

support

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US / səˈpɔ:t /

UK / səˈpɔrt, -ˈport /

A1
  • noun
  • Assistance or advice given to someone
  • Evidence that helps prove something is true
  • A thing to hold up or prevent from falling down
  • verb
  • To give assistance or advice to someone
  • To help prove or show that something is true
  • To hold up or prevent from falling down
  • Subtitles section
  • Starfish can regenerate arms, certain lizards can grow back severed tails, some flatworms can recreate their entire body from a single adult cell, and my skin will grow back together after a paper cut.
  • On some level, we can all do a little regeneration.
  • But if I cut my arm off, I'm not going to expect to grow a new one, right?
  • The wound would eventually be covered over with a rugged, fibrous matrix of the protein collagen, forming what we know as scar tissue, with a layer of skin on top, but I'm not going to grow a new appendage.
  • But that's not true for everyone.
  • The real superstars of limb regeneration are the members of the order Caudata, salamanders.
  • Cut off a salamander's leg?
  • Don't actually cut off a salamander's leg, you know what I mean.
  • And cells at the wound site won't form scar tissue, instead they'll transform into what researchers call a wound epidermis, which activates a wave of chemical instructions to the cells below.
  • Soon, the nerves in the stump begin to grow again, and mature muscle and tissue cells actually revert back to their immature state, sort of going back in time before they were specialized cells.
  • They then start streaming toward the wound, forming a mass called a blastoma.
  • These undifferentiated cells are a lot like stem cells, or what embryonic cells are like during development, before a gene is activated that tells them what they're going to be, like a liver, or a heart,
  • Or a skin cell.
  • But these undifferentiated cells were mature, and they have a terrific memory of what they used to be, like a muscle cell in a forelimb, or a cartilage cell in a leg joint.
  • This is how they take up their specific positions, and form new muscle, connective tissue, cartilage, and bone, until, boom!
  • The animal has a whole, shiny new leg.
  • We understand the basic method here, but researchers are still puzzled by the details.
  • Like, why does the wound epidermis form in the first place, and how does it trigger that reversion to the cells below it?
  • And just how do all those regenerating cells know where they should be, and what shape to take on?
  • The truth is, we just don't know… yet.
  • But researchers have recently pinpointed a cell that seems to be responsible for salamanders' remarkable regeneration capabilities.
  • All animals have a kind of repair cells called macrophages.
  • They rush into a wound site and eat up dead cells and pathogens, while triggering the release of other immune cells.
  • Mammals also use them to repair muscle, which got Dr. James Godwin of the Australian Regenerative Medicine Institute to thinking.
  • When Godwin and his colleagues reduced the number of macrophages at a salamander wound site, they found that regeneration took much longer.
  • And when they removed all the macrophages, the poor guys could no longer regrow limbs, but rather ended up with a lot of scar tissue, just like we do.
  • This suggests that regeneration is possible because those macrophage cells release some vital chemical signal that might trigger the undifferentiated cells to come in and do their thing.
  • So does that mean that we'll soon know how to help humans regenerate lost limbs?
  • Don't hold your breath.
  • Researchers say we're still a long way off from understanding the complexity of regeneration.
  • Plus, considering that it takes some small salamanders over a year to regenerate a limb, and larger ones over a decade, even if a human could grow back a lost leg, it could take them over 20 years.
  • Still, there are more immediate benefits and attainable goals that might come from this research, like how to make wounds heal faster and with little, if any, scarring.
  • Not a new arm, but still pretty awesome.
  • Thanks for joining me for this SciShow Dose, and thanks to our latest President of Space math help boards, where you can get free math help at any level, at any time of the day.
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