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The hope for early detection of Alzheimer's disease

Video vocabulary

only

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US / ˈəunli /

UK / ˈonli /

A1
  • adverb
  • Just one; just that amount or thing; not more than
  • Not very important or serious
  • Just that type of thing, person
  • Short time ago; not before a certain time
  • conjunction
  • Except; but

optimize

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US / ˈɒptɪmaɪz /

UK / ˈɑ:ptɪmaɪz /

B2
  • verb
  • To make as effective as possible

early

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US / ˈɜ:li /

UK / ˈɜ:rli /

A1
  • adjecitve
  • Happening or appearing before
  • adverb
  • Coming/happening before others in a time sequence
  • Happening sooner than expected

direct

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US / də'rekt /

UK / dɪˈrɛkt, daɪ- /

A2
  • adverb
  • Coming straight from something
  • verb
  • To tell someone in a very clear way to do something
  • To show the way by conducting or leading
  • To control the acting in a movie or play

reduction

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US / rɪ'dʌkʃn /

UK / rɪˈdʌkʃən /

B1
  • noun
  • Act of making something smaller
  • Amount that a price is decreased by

screen

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US / skri:n /

UK / skrin /

A2
  • noun
  • Wire net in a door or window to keep insects out
  • Displays in a theater on which movies are shown
  • Flat surface on a computer or TV showing images
  • verb
  • To hide or block something from being seen
  • To examine to find something, e.g. best candidate

far

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US / fɑ:(r) /

UK / fɑr /

A1
  • adjecitve
  • A long way away
  • Being a long way away
  • adverb
  • To a large degree or extent

reduce

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US / rɪ'dju:s /

UK / rɪˈdus, -ˈdjus /

A2
  • verb
  • To try to decrease, e.g. your weight if overweight
  • To boil a liquid until it has decreased in amount
  • To make something smaller in size, amount, level

surgery

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US / 'sɜ:dʒərɪ /

UK / ˈsɚdʒəri /

B1
  • noun
  • A doctor's office; health clinic
  • Medical operation involving cutting into body

where

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US / hwɛə /

UK / hwɛr, wɛr /

A1
  • conjunction
  • At or in the place which
  • In whatever place
  • pronoun
  • Word you use to ask the location of something

doctor

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US / ˈdɒktə(r) /

UK / ˈdɑːktɚ /

A1
  • noun
  • Person paid to help people become or stay healthy
  • Person awarded the highest university degree
  • verb
  • To treat someone's illness
  • To change something in order to trick someone

empower

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US / ɪm'paʊə(r) /

UK / ɛmˈpaʊɚ /

B2
  • verb
  • To give someone a power or ability

keep

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US / ki:p /

UK / kip /

A1
  • noun
  • Large, strong tower in the middle of a castle
  • Money spent on you so you can live in a place
  • verb
  • To continue doing something; not to stop
  • To stop balls going in a goal in sports
  • To not give back or return something
  • (Of food) to not spoil or not rot
  • To take possession of something to own, e.g. a pet
  • To have and continue to hold something
  • To do something that you have promised or agreed
  • To stay in a certain place or condition
  • To maintain the rules

company

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US / 'kʌmpənɪ /

UK / ˈkʌmpəni /

A1
  • noun
  • Good feeling from being with someone else
  • A business that sells things or provides services
  • Guests, especially in your home
  • Being with another person rather than alone

fifteen

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US / ˌfɪfˈti:n /

UK / fɪfˈtin /

A1
  • number
  • 15

help

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US / help /

UK / hɛlp /

A1
  • noun
  • Something given to enable a person to do something
  • Assistance given to someone in need
  • Someone who makes something easier or possible
  • verb
  • To act to enable a person to do something; assist
  • To make something better or less difficult

think

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US / θɪŋk /

UK / θɪŋk /

A1
  • verb
  • To have an idea about something without certainty
  • To have an idea, opinion or belief about something

and

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US / ənd /

UK / ənd, ən,ænd /

A1
  • conjunction
  • Used to refer to two or more things
  • Plus; in addition; on top of that
  • Used to introduce an action that follows another

fragment

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US / 'fræɡmənt /

UK / ˈfræɡmənt /

B1
  • noun
  • Part that is broken off of something
  • verb
  • To be broken into pieces
  • (Of computer file) to be broken into pieces

lot

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US / lɒt /

UK / lɑt /

A1
  • noun
  • What happens to a person in life from chance; fate
  • A group of people seen together
  • Item for sale at an auction
  • Small area of land used for a purpose e.g. parking

significantly

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US / sɪgˈnɪfɪkəntli /

UK / sɪɡˈnɪfəkəntlɪ /

A2
  • adverb
  • In a way that is important or noticeable
  • In a way that is meaningful

sugar

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US / ˈʃʊgə(r) /

UK / ˈʃʊɡɚ /

A2
  • noun
  • Substance which the body stores or uses for energy
  • Amount of sugar contained in a small spoon
  • Used to address someone you like or love
  • White sweet substance used to make foods sweeter
  • verb
  • To add, put on, or mix a food or drink with sugar

amyloid

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US / 'æmɪ'lɔɪd /

UK / 'æmɪ'lɔɪd /

A1
  • noun
  • Resembling starch

out

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US / aʊt /

UK / aʊt /

A1
  • adverb
  • No longer stylish (e.g. fashion)
  • Away from home, business, or the usual place
  • In a direction/movement away from inside or center
  • noun
  • Act when a batter cannot continue playing
  • verb
  • To tell people a secret

over

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US / 'əʊvə(r) /

UK / ˈovɚ /

A1
  • adverb
  • Finished; no longer happening
  • Towards the ground/away from a standing position
  • noun
  • A set of six consecutive balls bowled in cricket
  • other
  • Finished
  • preposition
  • Showing the relation when a thing is above another
  • On or covering something
  • Above or across something
  • More than you need
  • From one side to the other
  • In the direction of; toward

each

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US / i:tʃ /

UK / itʃ /

A1
  • determiner
  • Every one of two or more things
  • pronoun
  • Per one person or thing

ethical

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US / ˈeθɪkl /

UK / ˈɛθɪkəl /

B1
  • adjecitve
  • Morally right; following principles of goodness
  • Involving the choice between right and wrong

example

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US / ɪgˈzɑ:mpl /

UK / ɪɡˈzæmpəl /

A1
  • noun
  • Thing, person which represents a category

happen

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US / 'hæpən /

UK / ˈhæpən /

A1
  • verb
  • To take place or occur

method

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US / 'meθəd /

UK / ˈmɛθəd /

A2
  • noun
  • (Organized and planned) way of doing something

dynamic

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US / daɪˈnæmɪk /

UK / daiˈnæmik /

B1
  • adjecitve
  • Always active or energetic; getting things done

right

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US / raɪt /

UK / raɪt /

A1
  • adjecitve
  • Correct or true
  • The south side of you looking at the rising sun
  • adverb
  • Exactly in a place or time
  • Being appropriate for a particular event
  • In a straight or direct manner
  • noun
  • Something you are legally or morally allowed to do
  • Ideal of what is just and good
  • Political view based on conservatism
  • verb
  • To fix something previously wrong or unjust
  • To make upright, as a boat that has turned over

bill

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US / bɪl /

UK / bɪl /

A2
  • noun
  • Plan for a new law being discussed by a government
  • Sign or poster advertising something
  • Paper money; a bank note
  • Piece of paper showing what you have to pay
  • Hard, often pointed part of a bird's mouth
  • Person's name
  • verb
  • To request payment by handing over an invoice

tell

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US / tel /

UK / tɛl /

A1
  • verb
  • To (strongly) advise a person to do something
  • To be able to guess
  • To say or communicate information to someone
  • To inform, but without speaking; indicate
  • To have a negative effect on someone
  • To order someone to do something; command
  • To recognize something based on certain signs
  • To report something to an authority
  • To explain something or teach someone something

case

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US / keɪs /

UK / kes /

A1
  • noun
  • Container used to carry things, e.g. clothes
  • Set of facts about a crime
  • Set of facts about an event
  • Example or instance of something
  • verb
  • To find out about a place, as in planning to steal

find

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US / faɪnd /

UK / faɪnd /

A1
  • noun
  • Object discovered by chance
  • Things that have been discovered from searching
  • verb
  • To become aware of something that is happening
  • To discover or meet by chance
  • To decide if someone is guilty of a crime, or not
  • To learn through study, research, or effort
  • To discover something by looking for it

difficulty

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US / ˈdɪfɪkəlti /

UK / ˈdɪfɪˌkʌlti, -kəl- /

A1
  • noun
  • Something that is hard to do

get

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US / ɡet /

UK / ɡɛt /

A1
  • verb
  • To become affected by illness or disease
  • To begin to feel or understand an emotion or idea
  • To send or bring someone or something home, etc.
  • To go somewhere to obtain something
  • To (cause to) do a particular thing
  • To obtain, receive or be given something
  • To currently have
  • To prepare for use
  • To understand something being said or read

physician

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US / fɪˈzɪʃn /

UK / fɪˈzɪʃən /

B2
  • noun
  • A medical doctor

block

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US / blɒk /

UK / blɑk /

A2
  • noun
  • Solid piece of material used for building
  • A piece of wood, chocolate etc.
  • Hard piece of wood, stone etc. with straight edges
  • Building made up of offices or apartments
  • Area of a city divided by four streets
  • verb
  • To stop from going forward or making progress

down

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US / daʊn /

UK / daʊn /

A1
  • adjecitve
  • Being sad, sick, or unhappy
  • Not operating, working, or functioning as expected
  • adverb
  • In a sitting or lying position
  • Towards or on the ground, floor, or bottom
  • Written or copied onto a piece of paper or book
  • noun
  • A period of play in American Football
  • The soft, smooth hairs that cover a bird's body
  • preposition
  • Along something's path, course, or direction
  • Going from a higher position to a lower position
  • verb
  • To eat or drink very quickly and without stopping

family

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US / 'fæməlɪ /

UK / ˈfæmli /

A1
  • noun
  • Close group of people or organizations
  • A group of people who are related through blood
  • Group of related plants or animals

then

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US / ðen /

UK / ðɛn /

A1
  • adverb
  • A time that is not now
  • Following another thing in time or arrangement
  • Following on reasonably from what was just stated
  • At that time, not now

own

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US / əʊn /

UK / on /

A1
  • adjecitve
  • Belong to oneself
  • determiner
  • Yours, his, hers, etc.; not belonging to another
  • pronoun
  • (Something) belong to myself
  • verb
  • To have something as your property

about

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US / ə'baʊt /

UK / əˈbaʊt /

A1
  • adverb
  • To be ready to; going to
  • Nearly; approximately; roughly
  • Near; next to; close to
  • In every direction; in the area of
  • preposition
  • Concerning or of (a topic)

different

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US / ˈdɪfrənt /

UK / ˈdɪfrənt /

A1
  • adjecitve
  • Not of the same kind; unlike other things

even

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US / 'i:vn /

UK / ˈivən /

A1
  • adjecitve
  • Being equal in influence, power, possibility etc.
  • Being divided equally or fairly
  • (Of teams/contest) with similar chances of success
  • Smooth, level, or regular
  • Can be divided by 2; ending in 2, 4, 6, 8, or 0
  • At a regular, equally steady manner
  • Remaining steady and unchanging
  • adverb
  • (When this is surprising) as well; too
  • (Used to compare two things/stress the difference)
  • verb
  • To make something level; to flatten
  • To make something equal

health

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US / helθ /

UK / hɛlθ /

A1
  • noun
  • (Person, company) being in a good condition; well

impact

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US / 'ɪmpækt /

UK / ˈɪmˌpækt /

A2
  • noun
  • A striking effect or result to hit with force
  • Very strong influence
  • Act or force of one thing hitting something else
  • verb
  • To hit or strike someone or something with force

people

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US / 'pi:pl /

UK / ˈpipəl /

A1
  • noun
  • Persons sharing culture, country, background, etc.
  • Men, Women, Children

that

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US / ðæt /

UK / ðæt, ðət /

A1
  • adjecitve
  • The person or thing being talked about
  • Used to identify something both the speakers know
  • adverb
  • Used to reinforce adjectives and adverbs
  • To such a degree
  • conjunction
  • Used to connect a noun clause
  • Used to introduce an adverbial clause
  • Used to introduce a noun clause
  • determiner
  • Used as a noun to refer to something
  • pronoun
  • Referring an object far away
  • Used to refer to the relative pronoun ‘which’

what

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US / wɒt /

UK / hwɑt, hwʌt, wɔt, wʌt,hwət, wət /

A1
  • pronoun
  • Thing or things that; the same kind as
  • Used to emphasize something you are about to say
  • adjecitve
  • Used to refer to a particular amount, or number
  • Used to place emphasis on a particular quality
  • adverb
  • To a certain degree
  • determiner
  • Question words used for asking for information
  • exclamation
  • Used to express excitement, shock, or surprise
  • Used to ask people to repeat something they said

week

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US / wi:k /

UK / wik /

A1
  • noun
  • Period of seven days from Sunday to Saturday

buildup

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US / 'bɪldˌʌp /

UK / 'bɪldˌʌp /

C2
  • noun
  • Making people feel excited about some new event

interest

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US / 'ɪntrəst /

UK / ˈɪntrɪst, -tərɪst, -ˌtrɛst /

A1
  • noun
  • Best or most advantageous thing for someone
  • Activity or subject one enjoys doing or learning
  • Fee for borrowing money
  • verb
  • To make someone want to know about something
  • To persuade to do, become involved with something

loss

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US / lɒs /

UK / lɔ:s /

A2
  • noun
  • Friend, family, or other loved person's death
  • Decrease or decline in quantity or amount
  • Experience or state of failing to have or keep
  • A situation when you lose a game
  • Process of failing to have or keep something
  • Difficulty or trouble caused by someone's leaving
  • Situation when more money is spent than is earned

lifestyle

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US / ˈlaɪfstaɪl /

UK / ˈlaɪfˌstaɪl /

B1
  • noun
  • The type of life that you have; the way you live

sample

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US / ˈsɑ:mpl /

UK / ˈsæmpl /

A2
  • noun
  • A small quantity of something used as a taster
  • verb
  • To try (e.g. food, drink), to see if you like it

ali

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US / ɑ:ˈli: /

UK / ɑˈli /

A1
  • noun
  • Fourth caliph of Islam who is considered to be the first caliph by Shiites; he was a cousin and son-

could

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US / kəd /

UK / kʊd /

A1
  • other
  • Past form of 'can' to mean have ability
  • Used to ask for something politely, or to offer

know

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US / nəʊ /

UK / noʊ /

A1
  • verb
  • To be familiar with a person or place, thing
  • To feel sure or be convinced about something
  • To discover or be aware of something
  • To be able to distinguish
  • To have knowledge of things

see

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US / si: /

UK / si /

A1
  • verb
  • To go on a date with someone
  • To predict whether something is, or will be true
  • To understand what someone says
  • To use your eyes to look at something
  • To visit a place often for sightseeing or pleasure
  • To visit or meet with someone
  • To find out by waiting or looking
  • To watch (a game, movie or TV show)

blood

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US / blʌd /

UK / blʌd /

A2
  • adjecitve
  • Related by birth; family
  • noun
  • Red liquid in the bodies of people and animals
  • verb
  • To be initiated into something, e.g. a secret club

calculate

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US / 'kælkjʊleɪt /

UK / ˈkælkjəˌlet /

B2
  • verb
  • To find an answer using mathematics
  • To make an educated guess about something

fundamental

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US / ˌfʌndəˈmentl /

UK / ˌfʌndəˈmɛntl /

A2
  • adjecitve
  • Forming a necessary part, base, or core
  • noun
  • A basic part of something
  • (Music) the lowest note in a harmony

increase

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US / ɪn'kri:s /

UK / ɪnˈkris /

A1
  • noun
  • Fact of increasing; amount something grows by
  • verb
  • To make or become larger in size or amount

history

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US / 'hɪstrɪ /

UK / ˈhɪstəri /

A2
  • noun
  • Established pattern or record
  • Study of past events as an academic subject

exercise

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US / 'eksəsaɪz /

UK / ˈɛksɚˌsaɪz /

A2
  • noun
  • Physical activity to increase health and strength
  • Set of questions in a text book
  • verb
  • To work out to become stronger and healthier
  • To retain your ability or practice your skills

have

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US / həv /

UK / hæv /

A1
  • verb
  • To drink, smoke, eat or use something
  • To experience the effects of something
  • To organize an event, or join in an activity
  • To own, possess, or hold something
  • To cause to happen or produce a particular effect

last

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US / lɑ:st /

UK / læst /

A1
  • adjecitve
  • Most recent; the latest
  • The one before
  • adverb
  • Final; with nothing following; after all others
  • Most recent; the latest
  • determiner
  • The one at the end
  • verb
  • To remain or continue for a certain period of time

part

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US / pɑ:t /

UK / pɑ:rt /

A1
  • adjecitve
  • To some degree; half; not fully
  • noun
  • Division of a book
  • Ratio of something, e.g. 3 of gin, 1 of tonic
  • A line in a person's hair, made with a comb
  • Character an actor plays on stage, movie, or TV
  • Some, but not all of a specific thing
  • Role in causing something to happen
  • verb
  • To make a line in a person's hair, by using a comb
  • To move two things apart creating a space
  • To leave someone, or to break off a relationship

sixty

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US / 'sɪkstɪ /

UK / ˈsɪksti /

A1
  • number
  • 60

percent

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US / pə'sent /

UK / pɚˈsɛnt /

A2
  • adverb
  • One one-hundredth of a whole; the symbol %

recently

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US / ˈri:sntli /

UK / 'risṇtlɪ /

A1
  • adverb
  • Just a while ago; not long ago

with

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US / wɪð /

UK / wɪð, wɪθ /

A1
  • preposition
  • As an employee of a certain company
  • Against something or someone
  • By using something as a means
  • Due to; because of
  • Including
  • Possessing as a feature
  • Related to
  • (Of the manner/attitude by which you do something)
  • Used to express that people or things are together

clear

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US / klɪə(r) /

UK / klɪr /

A1
  • adjecitve
  • Empty; without anything in it or on it
  • Being certain and without doubt
  • Being without any streaks, spots, or cracks
  • Easy to understand; well-explained; obvious
  • adverb
  • Completely; entirely; through the whole of
  • Away from; free from
  • verb
  • To recover from or remove a problem
  • To get rid of the entire contents of
  • To give permission for something to happen
  • To make a place or surface empty by removing
  • To prove that someone is not guilty or to blame

problem

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US / ˈprɒbləm /

UK / ˈprɑbləm /

A1
  • adjecitve
  • Causing trouble
  • noun
  • Something difficult to deal with or causes trouble
  • Question to show understanding of a math concept

make

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US / meɪk /

UK / mek /

A1
  • noun
  • Product made by a particular company; brand
  • verb
  • To arrange or prepare something e.g. dinner
  • To get to (a place) on time
  • To gain the status of (teacher, lawyer, etc.)
  • To create something by putting things together
  • To earn a certain amount of money at a job
  • To cause or force a person to do something
  • To cause something to happen or be formed

mediterranean

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US / ˌmedɪtəˈreɪniən /

UK / ˌmɛdɪtəˈreniən, -ˈrenjən /

A1
  • adjecitve
  • Describing the sea between Italy and Africa

treat

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US / tri:t /

UK / trit /

A1
  • noun
  • Something you buy for others as a surprise present
  • something that tastes good and that is not eaten often
  • verb
  • To pay for the food or enjoyment of someone else
  • To use medical methods to try to cure an illness
  • To act in a certain way toward someone

other

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US / 'ʌðə(r) /

UK / ˈʌðər /

A1
  • adjecitve
  • A thing different from that mentioned
  • determiner
  • (Something) else; not the first (one)
  • pronoun
  • Being the one and only thing of that category

one

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US / wʌn /

UK / wʌn /

A1
  • pronoun
  • You; we; people in general; someone
  • The thing or person previously referred to
  • adjecitve
  • Used to refer to people generally
  • Being a strong example of (something mentioned)
  • number
  • Number 1

revolutionize

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US / ˌrevə'lu:ʃənaɪz /

UK / revəˈluːʃəˌnaɪz /

B1
  • verb
  • To completely change so that it is much better

than

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US / ðən /

UK / ðən /

A1
  • conjunction
  • Used to compare two things that are not equal

stress

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US / stres /

UK / strɛs /

A2
  • noun
  • Emphasis on part of a word or sentence
  • Pressure on something or someone
  • A state of mental tension, worry due to problems
  • verb
  • To emphasize one or more parts of a word, sentence
  • To put pressure on something or someone
  • To say your opinion strongly
  • To be in a state of mental tension due to problems

mci

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US / /

UK / /

A1
  • abbreviation
  • MCI is an acronym

term

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US / tɜ:m /

UK / tɚm /

A1
  • noun
  • Conditions applying to an agreement, contract
  • Length of time something is expected to happen
  • Fixed period of weeks for learning at school
  • The (precise) name given to something
  • verb
  • To call; give a name to

aerobic

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US / eəˈrəʊbɪk /

UK / eˈroʊbɪk /

B2
  • adjecitve
  • Needing oxygen to live

alone

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US / ə'ləʊn /

UK / əˈlon /

A1
  • adjecitve
  • Apart from others
  • Without equal
  • adverb
  • Without anyone or anything else

congestion

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US / kənˈdʒestʃən /

UK / kənˈdʒestʃən /

B2
  • noun
  • Excessive accumulation of blood/fluid in the body

might

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US / maɪt /

UK / maɪt /

A1
  • other
  • Used to politely request an action
  • Used to express that something could happen
  • Power, strength, force or influence

person

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US / 'pɜ:sn /

UK / 'pɜ:rsn /

A1
  • noun
  • Man, woman or child

the

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US / ðə /

UK / ðə /

A1
  • article
  • Used to refer to something already mentioned
  • Used to show there is only one of something
  • determiner
  • Used to describe all of a family

may

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US / meɪ /

UK / me /

A1
  • noun
  • 5th month of the year
  • other
  • Used to express a desire
  • Expresses permission, possibility or probability
  • Used to show that a thing could be true

this

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US / ðɪs /

UK / ðɪs /

A1
  • adjecitve
  • Used to indicate something already been discussed
  • Used to indicate something happening around now
  • adverb
  • An indication by a physical motion or gesture
  • A specific amount of
  • determiner
  • Person, thing, or idea near you
  • pronoun
  • Person, thing that has already been discussed

also

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US / 'ɔ:lsəʊ /

UK / ˈɔlso /

A1
  • adverb
  • In addition; too; in a similar way

clump

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US / klʌmp /

UK / klʌmp /

B2
  • noun
  • Mass or pile of something such as soil
  • Small group of trees, etc. growing near each other

critical

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US / ˈkrɪtɪkl /

UK / ˈkrɪtɪkəl /

A2
  • adjecitve
  • Making a negative judgment of something
  • Being important or serious; vital; dangerous
  • Most important part

identify

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US / aɪ'dentɪfaɪ /

UK / aɪˈdɛntəˌfaɪ /

B1
  • verb
  • To indicate who or what someone or something is

how

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US / haʊ /

UK / haʊ /

A1
  • adjecitve
  • To what degree? in what amount?
  • adverb
  • (Used to explain the way to do something)
  • exclamation
  • For what purpose or reason?
  • (Used to ask someone or something's condition)

year

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US / jə: /

UK / jɪr /

A1
  • noun
  • Unit of time equal to 12 months or 365 or 366 days
  • Used to refer to the age of a person

you

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US / jʊ /

UK / ju /

A1
  • pronoun
  • Person someone is speaking or writing to
  • Person or people in general

patient

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US / 'peɪʃnt /

UK / ˈpeʃənt /

A2
  • adjecitve
  • Not getting annoyed when things take a long time
  • noun
  • Person who receives medical treatment or care

specific

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US / spəˈsɪfɪk /

UK / spɪˈsɪfɪk /

A2
  • adjecitve
  • Precise; particular; just about that thing
  • Concerning one particular thing or kind of thing

diabete

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US / /

UK / /

A1

eat

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US / i:t /

UK / it /

A1
  • verb
  • To put food in your mouth

imagine

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US / ɪ'mædʒɪn /

UK / ɪˈmædʒɪn /

A1
  • verb
  • To think creatively about; form mental picture of

while

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US / waɪl /

UK / hwaɪl, waɪl /

A1
  • conjunction
  • In spite of the fact that; although
  • During the time that; at the same time
  • noun
  • Short amount of time

beneficial

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US / ˌbenɪˈfɪʃl /

UK / ˌbɛnəˈfɪʃəl /

B1
  • adjecitve
  • Giving an advantage, having a helpful effect

mild

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US / maɪld /

UK / maɪld /

A2
  • adjecitve
  • Gentle in nature or behavior
  • Being neither too cold nor too hot

always

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US / 'ɔ:lweɪz /

UK / ˈɔlwez,-wɪz,-wiz /

A1
  • adverb
  • For a very long time
  • At all times; in every situation
  • For ever

diet

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US / 'daɪət /

UK / ˈdaɪɪt /

A2
  • noun
  • Plan of eating to reduce weight or improve health
  • other
  • The usual food and drink consumed by an organism (person or animal)
  • verb
  • To eat special or less food, as to lose weight

indeed

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US / ɪnˈdi:d /

UK / ɪnˈdid /

A2
  • adverb
  • Actually; in fact; in reality

many

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US / 'menɪ /

UK / ˈmɛni /

A1
  • determiner
  • Used to refer a large number of things

speak

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US / spi:k /

UK / spik /

A1
  • verb
  • To be able to use a certain language
  • To use words to tell information, express thoughts

use

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US / ju:s /

UK / ju:s /

A1
  • noun
  • Ability to employ something
  • Need to enable it to work
  • Permission to do something with something
  • Act of spending money
  • Operation of a machine for its function
  • verb
  • To have; to eat, drink, consume etc.
  • To need to operate or work
  • To operate a machine, e.g. a computer
  • To treat a person badly
  • To do something with, for a task or purpose

astonish

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US / ə'stɒnɪʃ /

UK / əˈstɑnɪʃ /

A2
  • verb
  • To cause someone to feel great wonder or surprise

area

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US / 'eərɪə /

UK / ˈɛriə /

A1
  • noun
  • Amount of measured space
  • A specific section or space; part of a region
  • A subject or field of study

basic

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US / 'beɪsɪk /

UK / ˈbesɪk /

A1
  • adjecitve
  • At the most important or easiest (beginner) level

impairment

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US / ɪmˈpeəmənt /

UK / ɪmˈpermənt /

B2
  • noun
  • Damage leading to lower strength or quality

memory

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US / 'memərɪ /

UK / ˈmɛməri /

A2
  • noun
  • Ability of the mind to call back past things
  • Space for the storage of information on a computer
  • Something that has been remembered

here

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US / hɪə(r) /

UK / hɪr /

A1
  • adverb
  • In this place; at this location, position or time

lose

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US / lu:z /

UK / luz /

A1
  • verb
  • To be unable to keep in check or control something
  • To decrease in value or quantity (e.g. weight)
  • To stop having certain qualities or abilities
  • To stop having or being entitled to
  • To fail to win something that is being contested
  • To be unable to find something you once had
  • To be dependent on someone (used with 'not')

new

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US / nju: /

UK / nu, nju /

A1
  • adjecitve
  • Not old, recently born, built or made
  • Being or doing something for the first time
  • Not felt, seen or known previously
  • Having been recently bought or obtained

scan

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US / skæn /

UK / skæn /

B1
  • noun
  • A look inside the body with a special machine
  • verb
  • To look inside of the body with a special machine
  • To look at something very quickly for information
  • To look at all parts to find something
  • To make a digital copy of an image or a paper

strategy

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US / 'strætədʒɪ /

UK / ˈstrætədʒi /

A2
  • noun
  • Careful plan or method for achieving a goal
  • other
  • Branch of military dealing with command

tool

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US / tu:l /

UK / tul /

A2
  • noun
  • Device used to make things, e.g. a hammer
  • verb
  • To provide a workshop with the right equipment

try

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US / traɪ /

UK / traɪ /

A1
  • noun
  • Act of putting the ball over the rugby goal line
  • verb
  • To make an effort, to attempt to do something
  • To examine someone or something in a court of law
  • To test to see if it is good or you like it
  • To make a person go through hardship; test
  • To examine something to see if it works

day

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US / deɪ /

UK / de /

A1
  • noun
  • A period of 24 hours beginning at midnight
  • The period of time when it is light outside
  • Person's name

develop

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US / dɪ'veləp /

UK / dɪˈvɛləp /

A1
  • verb
  • To explain something in steps and in detail
  • To create or think of something
  • To grow bigger, more complex, or more advanced
  • To make a photograph from film

dramatically

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US / drə'mætɪklɪ /

UK / drəˈmætɪkl:ɪ /

B1
  • adverb
  • In a sudden or extreme manner

point

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US / pɔɪnt /

UK / pɔɪnt /

A1
  • noun
  • An item to be discussed
  • Small spot or dot
  • Fact or detail
  • Feature of something
  • The size of the text on a page or screen
  • A certain time or stage in a process
  • Certain position in time or space
  • Idea or fact you try to convince people about
  • Measurement of scores in a game, sport
  • Sharp end of something, e.g. a pen or pin
  • verb
  • To face a certain direction, e.g. north
  • To indicate something with your finger to others

symptomatic

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US / ˌsɪmptəˈmætɪk /

UK / ˌsɪmtəˈmætɪk, ˌsɪmp- /

B1
  • adjecitve
  • Characteristic or indicative of a disease

blotch

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US / blɒtʃ /

UK / blɑ:tʃ /

C2
  • noun
  • Marks, spots or blots that spoil something

cognitive

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US / ˈkɒgnətɪv /

UK / ˈkɑɡnɪtɪv /

C1
  • adjecitve
  • The process of knowing and remembering

control

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US / kən'trəʊl /

UK / kənˈtrol /

A1
  • noun
  • A device designed to operate a machine
  • Participant in experiment that is left untouched
  • Act to dominate or command; make manageable
  • A law limiting the growth or spread of something
  • A place which overseas or manages e.g. a factory
  • verb
  • To direct or influence the behavior of something

pace

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US / peɪs /

UK / pes /

A2
  • noun
  • Rate of speed at which something moves or happens
  • Single step, often used to measure a distance
  • verb
  • To set and control your speed, as in a race
  • To walk with slow purposeful steps

occur

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US / əˈkɜ:(r) /

UK / əˈkɚ /

A2
  • verb
  • To come to pass or to happen

those

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US / ðəʊz /

UK / ðoz /

A1
  • determiner
  • The people or things we are talking about
  • pronoun
  • The objects far from the speaker

just

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US / dʒʌst /

UK / dʒʌst /

A1
  • adjecitve
  • Proper or appropriate; as is deserved
  • Doing or being what is right or fair
  • Legally correct; having enough evidence
  • adverb
  • Almost; nearly
  • Exactly at the time of
  • Exactly (the same as, like)

line

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US / laɪn /

UK / laɪn /

A1
  • noun
  • Border that divides two places or regions
  • Long crease in the skin, often from age
  • Mark that is long, straight and very thin
  • Row of words, letters or numbers that are written
  • Telephone connection
  • People waiting one behind the other; queue
  • Long thin wire, e.g. for electrical signal
  • verb
  • To put material along the inside of something

pet

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US / pet /

UK / pɛt /

A2
  • adjecitve
  • Favorite
  • noun
  • Animal kept by a person for company and friendship
  • A favorite thing or person
  • verb
  • To gently touch an animal or person; stroke
  • To kiss and cuddle, sometimes in a sexual way

recover

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US / rɪ'kʌvə(r) /

UK / rɪ'kʌvər /

A2
  • verb
  • To return to a prior normal condition
  • To get back something that was lost

report

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US / rɪ'pɔ:t /

UK / rɪˈpɔrt, ˈport /

A1
  • noun
  • Account of the necessary facts and information
  • The telling of news in the media
  • Official statement about something
  • verb
  • To submit a report or bill to the government
  • To write in a newspaper or speak on a news program
  • To state something officially
  • To officially present yourself to an authority
  • To describe something by telling it to others

technology

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US / tek'nɒlədʒɪ /

UK / tɛkˈnɑlədʒi /

A2
  • noun
  • Use or knowledge of science in industry etc.

question

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US / 'kwestʃən /

UK / ˈkwɛstʃən /

A1
  • noun
  • Issue or problems you are dealing with
  • What you ask about; issue
  • verb
  • To ask for or try to get information
  • To have or express concerns or uncertainty

plaque

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US / plæk /

UK / plæk /

B2
  • noun
  • Sign on building as a reminder of an event/person
  • Hard matter that can build up on your teeth

overall

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US / ˌəʊvər'ɔ:l /

UK / ˈovɚˌrɔl /

A2
  • adjecitve
  • Viewed as a whole; in general, not as details

threshold

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US / 'θreʃhəʊld /

UK / ˈθrɛʃˌold, -ˌhold /

B2
  • noun
  • Degree or level at which something begins

start

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US / stɑ:t /

UK / stɑrt /

A1
  • noun
  • First time or place that a thing exists; beginning
  • First opportunity to achieve something, e.g. a job
  • Sudden action or movement because you are scared
  • other
  • Beginning of something in place or time
  • verb
  • To do, be or happen for the first time; begin
  • To turn something on

test

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US / test /

UK / test /

A1
  • noun
  • A medical examination
  • Action to establish the truth or nature of
  • Examination; questions to measure knowledge
  • verb
  • To be given a medical examination
  • To try to establish the truth or nature of
  • To ask a series of questions to measure knowledge

well

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US / wel /

UK / wɛl /

A1
  • adjecitve
  • Being in a fortunate, good condition or state
  • Healthy and in good condition
  • adverb
  • In an acceptable, proper, or successful manner
  • In a complete, total, or full manner
  • A great and considerable degree
  • In a successful way, in a good or satisfactory way
  • exclamation
  • Used to begin or continue a particular statement
  • Used to show you want to start saying something
  • Used to express that you are waiting for a reply
  • You say this to change the topic of a conversation
  • Used to indicate you are making a final remark
  • noun
  • Long deep hole in the ground to get water
  • verb
  • To cause your eyes to fill with tears

efficiently

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US / ɪ'fɪʃntlɪ /

UK / ɪˈfɪʃəntlɪ /

A2
  • adverb
  • In a way that does not create waste

individual

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US / ˌɪndɪˈvɪdʒuəl /

UK / ˌɪndəˈvɪdʒuəl /

A2
  • adjecitve
  • Made for use by one single person
  • Having a distinct manner different from others
  • noun
  • Single person, looked at separately from others

hobby

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US / ˈhɒbi /

UK / ˈhɑ:bi /

A1
  • noun
  • Regular activity done in free time, for pleasure

much

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US / mʌtʃ /

UK / mʌtʃ /

A1
  • adjecitve
  • Very; to a high level or degree
  • adverb
  • A lot; large amount; a high degree of
  • Nearly; basically
  • On many occasions; often
  • noun
  • A large amount; a great quantity

positive

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US / ˈpɒzətɪv /

UK / ˈpɑzɪtɪv /

A2
  • adjecitve
  • Showing agreement or support for something
  • Being sure about something; knowing the truth
  • Having the charge produced by electrons
  • Being good or useful
  • Showing that a chemical is present in a test

communicate

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US / kə'mju:nɪkeɪt /

UK / kəˈmjunɪˌket /

A2
  • verb
  • To give and exchange information

for

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US / fə(r) /

UK / fɔr,fə /

A1
  • preposition
  • Used to show the purpose, or need of something

therapy

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US / 'θerəpɪ /

UK / ˈθɛrəpi /

B2
  • noun
  • Treatment to help cure an illness

time

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US / taɪm /

UK / taɪm /

A1
  • noun
  • Speed at which music is played; tempo
  • Point as shown on a clock, e.g. 3 p.m
  • Number of hours, minutes needed to do something
  • Occasion when something happens
  • Period or occasion that something occurred
  • Period in history or the past
  • Something measured in minutes, hours, days, etc.
  • How long an event takes; duration
  • verb
  • To check speed at which music is performed
  • To choose a specific moment to do something
  • To measure how long an event takes, e.g. a race
  • To schedule something to occur at a specific moment

link

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US / lɪŋk /

UK / lɪŋk /

A2
  • noun
  • Any one of the rings that are part of a chain
  • Connection between two or more things or people
  • Webpage item you click to go to another webpage
  • verb
  • To join or connect together

self

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US / self /

UK / sɛlf /

A1
  • noun
  • Person's own interests or desires
  • Person that someone really is
  • Particular aspect of someone's personality
  • Person, usually someone already been mentioned

approach

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US / ə'prəʊtʃ /

UK / əˈprəʊtʃ /

A2
  • noun
  • Means of reaching a place, often a road or path
  • Request of someone with a specific goal in mind
  • Specific way to handle a project, task, problem
  • verb
  • To get close to reaching something or somewhere
  • To request someone to do something specific

alcohol

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US / 'ælkəhɒl /

UK / ˈælkəˌhɔl,-ˌhɑl /

B1
  • noun
  • A colorless liquid that can catch fire (C2H5OH)
  • Drinks such as wine, whiskey, beer

change

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US / tʃeɪndʒ /

UK / tʃendʒ /

A1
  • noun
  • Exchange of one set of clothes for another
  • Money in the form of coins instead of paper
  • Money returned after giving too much
  • Act of making or becoming something else
  • verb
  • To exchange one set of clothes for another
  • To exchange one kind of money for another
  • To replace something with another thing
  • To make or become something else
  • To go from one train, bus, etc. and go to another

simple

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US / 'sɪmpl /

UK / ˈsɪmpəl /

A1
  • adjecitve
  • Not hard to understand or do; not complex
  • Having only a few parts; not complex
  • Being ordinary or normal
  • Being plain; without a lot added for style

result

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US / rɪ'zʌlt /

UK / rɪˈzʌlt /

A2
  • noun
  • Something produced through tests or experiments
  • Final score of a competition, election or game
  • verb
  • To be the outcome of other causes and effects

show

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US / ʃəʊ /

UK / ʃo /

A1
  • noun
  • False display of love, emotion or action
  • An event for displaying or promoting goods
  • Play, opera or theater production
  • Presentation that is broadcast on TV or radio
  • verb
  • To be easily seen or displayed
  • To display your emotions or feelings
  • To let someone see something; display
  • To explain or teach how something is done
  • To lead someone somewhere; point them to something
  • To prove something to be true, correct
  • To reveal or allow something to be seen

infusion

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US / ɪnˈfju:ʒn /

UK / ɪnˈfjuʒən /

B2
  • noun
  • Extraction of materials by soaking in liquids

believe

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US / bɪ'li:v /

UK / bɪˈliv /

A1
  • verb
  • To think or accept that something is true
  • To have a particular opinion about something

human

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US / 'hju:mən /

UK / ˈhjumən /

A1
  • adjecitve
  • Concerning or characteristic of people
  • noun
  • A person; a man, woman or child

look

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US / lʊk /

UK / lʊk /

A1
  • noun
  • Person's beauty or physical attractiveness
  • Particular style of dress, clothes, or appearance
  • The way someone, something appears to be
  • Act of searching for or examining something
  • verb
  • To appear to be; seem

red

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US / red /

UK / rɛd /

A1
  • adjecitve
  • Being the color of blood

all

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US / ɔ:l /

UK / ɔl /

A1
  • adverb
  • Completely; totally
  • determiner
  • Being every one of something
  • pronoun
  • 100% of something; the complete amount

fast

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US / fɑ:st /

UK / fæst /

A1
  • adjecitve
  • In a way that is difficult to move or change
  • Moving or able to move quickly
  • Showing time that is later than the actual time
  • adverb
  • With a great deal of speed
  • noun
  • Period of time when a person chooses not to eat
  • verb
  • To refuse food for a long time

hypertension

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US / ˌhaɪpəˈtenʃn /

UK / ˌhaɪpərˈtenʃn /

B2
  • noun
  • Condition marked by abnormally high blood pressure

who

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US / hu: /

UK / hu /

A1
  • pronoun
  • Which person
  • Used to introduce information about people

beta

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US / 'bi:tə /

UK / 'beɪtə /

B2
  • noun
  • Test version of a product or software

prove

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US / pru:v /

UK / pruv /

A2
  • verb
  • To demonstrate truth by providing evidence

management

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US / 'mænɪdʒmənt /

UK / ˈmænɪdʒmənt /

A2
  • noun
  • People who are in control of a business or group
  • The process of running an organization

obesity

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US / əʊ'bi:sətɪ /

UK / oˈbisɪti /

B2
  • noun
  • State of being so fat it can harm your health

their

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US / ðɛː /

UK / ðer /

A1
  • determiner
  • Belonging to them

symptom

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US / 'sɪmptəm /

UK / ˈsɪmtəm, ˈsɪmp- /

B1
  • noun
  • Sign that suggests that there is a problem

way

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US / weɪ /

UK / we /

A1
  • adverb
  • Used to emphasize the amount of something
  • noun
  • Particular aspect of something being thought about
  • One of various choices that could be made
  • Particular existing condition or state
  • (Often long) distance or length of time
  • How something is done
  • Route to go to a place
  • Small street
  • Usual behavior, emotions or habits of someone

risk

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US / rɪsk /

UK / rɪsk /

A1
  • noun
  • Actions that cause potential problems
  • verb
  • To do something potentially dangerous or foolish

sleep

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US / sli:p /

UK / slip /

A1
  • noun
  • Substance in a person's eyes after waking up
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they

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US / ðeɪ /

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  • pronoun
  • Two or more people, animals, or things

very

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US / 'verɪ /

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  • Concerning a large degree or amount
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but

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US / bət /

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cut

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  • noun
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  • Small opening made using a sharp object, knife
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especially

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fifty

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US / 'fɪftɪ /

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  • number
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can

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US / kæn /

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  • noun
  • A metal container for storing food
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deliver

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  • To give birth to a child; help a woman give birth
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potentially

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usually

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want

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protein

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disease

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  • Introduction to Video Content
  • Alzheimer's disease is a devastating neurodegenerative disorder that affects millions of people worldwide. It is characterized by the progressive impairment of cognitive function, leading to memory loss, confusion, and eventually, the inability to perform daily tasks. Currently, there is no cure for Alzheimer's disease, and available treatments can only help manage the symptoms to some extent.However, there is new hope on the horizon. A recent report on Sixty Minutes highlights a groundbreaking approach to brain surgery that has the potential to revolutionize the treatment of Alzheimer's. Dr. Ali Rezai, a renowned neurosurgeon, has been utilizing ultrasound technology to deliver therapeutics more efficiently to specific regions of the brain in Alzheimer's patients.The results of Dr. Rezai's experimental procedure are nothing short of astonishing. Through the use of ultrasound, he has successfully reduced the buildup of beta amyloid plaque in the brains of Alzheimer's patients. Beta amyloid plaque is a protein fragment that accumulates in the brain over time, but in individuals with Alzheimer's, it accumulates at a much faster rate. These plaques clog the "roads" of the brain, obstructing communication between neurons and impairing cognitive function.Dr. Rezai's technique targets these plaques directly and significantly reduces their presence, as shown by red blotches in brain scans. Compared to patients who received only standard infusion treatment, those who underwent the ultrasound-assisted procedure experienced a 50% greater reduction in plaque buildup. This breakthrough offers new hope for the early detection and intervention of Alzheimer's disease.The development of effective treatments for Alzheimer's has been a longstanding challenge due to the complexity of the disease. While beta amyloid plaques are just one aspect of the disease pathology, they have attracted significant attention in recent years. Clearing these plaques from the brain has emerged as a promising therapeutic approach, and Dr. Rezai's ultrasound technology may hold the key to achieving this goal.The accumulation of beta amyloid plaques reaches a critical threshold after around fifteen to twenty years, marking the onset of noticeable symptoms. At this stage, individuals may experience difficulties with navigation, memory loss, and problems with thinking and reasoning. It is crucial to intervene at an early stage to slow down or halt the progression of the disease.The potential of ultrasound technology in Alzheimer's treatment lies in its ability to deliver therapeutics directly to targeted areas of the brain. By using focused ultrasound waves, Dr. Rezai can safely and non-invasively break down the plaques and enhance the brain's ability to clear them away. This approach offers a more precise and efficient alternative to traditional methods of drug delivery, which often involve systemic administration with limited specificity.While Dr. Rezai's findings are highly promising, further research is needed to validate and refine this innovative approach. The potential impact of ultrasound technology in Alzheimer's treatment extends beyond plaque reduction, as it opens up new possibilities for the development of targeted therapeutics and personalized interventions.In conclusion, the early detection and treatment of Alzheimer's disease are crucial for improving outcomes and enhancing the quality of life for patients. Dr. Rezai's groundbreaking use of ultrasound technology offers hope for a future where Alzheimer's can be effectively treated and potentially even prevented. With continued research and innovation, we may be on the verge of a paradigm shift in the management of this devastating disease.
  • Subtitles section
  • This week on Sixty Minutes, we reported on a cutting edge approach to brain surgery that could revolutionize treatment for Alzheimer's disease.
  • Over the last year, Dr. Ali Rezai has been using ultrasound technology to more efficiently deliver therapeutics to specific parts of the brain in patients with Alzheimer's.
  • The results he showed us were astonishing.
  • So you can see here in this case.
  • Seen here in red blotches, beta amyloid plaque, a buildup of protein believed to be linked to the cognitive impairment in those with Alzheimer's, was dramatically reduced in those patients, fifty percent more than other parts of the brain treated with an infusion alone.
  • amyloid, the plaques.
  • There are protein fragments that accumulate in everybody's brain over time.
  • In people with Alzheimer's, it accumulates much faster.
  • So imagine your roads in your brain get blocked with congestion and lots of these protein clumps.
  • So the brain cannot communicate because the roads are blocked and they keep on accumulating and impacting function.
  • And what happens is you reach a critical threshold.
  • At that point, usually about fifteen to twenty years, you're accumulating these proteins, these plaques in the brain, at a higher pace than you can
  • Because we always clear the plaques.
  • We have plaques every day.
  • At nights when you sleep, plaques are cleared, at which time you start having symptoms.
  • For example, people cannot find their way around.
  • They get lost.
  • They can't do a bill or calculate a tip.
  • and problems with memory and thinking occurs.
  • It's just one of the areas impacted with Alzheimer's.
  • There's many other factors, but this beta amyloid plaques are really becoming more and more of interest in terms of development of new therapeutic approaches for them to clear this plaques.
  • We also spoke with Dr. Rezai about new developments in blood testing that could help doctors identify patients who are at risk for Alzheimer's disease.
  • There are now blood tests that allow you to look at your blood test and look at plaques in your blood as a potential screening tool, even if you're not symptomatic or even if you don't know if you have Alzheimer's.
  • So you could potentially look at your blood sample.
  • You wouldn't even need a scan to know if you might have plaque buildup in the brain?
  • Indeed, so that technology is out there.
  • And recently, there's been a lot of progress there.
  • So you can do a blood test that tells you that you have beta amyloid.
  • And then the physicians can do further studies.
  • It's an important, simple screening tool.
  • And then you can get a brain scan, a PET scan, that basically looks at how much of these protein plaques you have in your brain is beta amyloid.
  • It's got a lot of ethical questions, what you would do with it.
  • Each person needs to look at their own self and what they want to do with it.
  • Right now, we're only doing it for people who have early Alzheimer's, very early mild cognitive impairment, or MCI.
  • But I can see potentially a time in the future where people can say, I want to test my blood.
  • I have a family history of Alzheimer's.
  • So I want to know if I have beta amyloid in my blood.
  • And if I do, maybe I want to get a brain scan to see if I have amyloid in my brain.
  • And it's empowering for an individual to know what may be down the line.
  • You may not get Alzheimer's, but then you know that you have increased beta amyloid in your blood and in your brain.
  • And I want to make a point that's important.
  • It's not just beta amyloid as the only cause of Alzheimer's.
  • There are many factors.
  • But right now, it seems to be a key area where therapeutics are being directed with pharma and companies developing strategies to clear that beta amyloid.
  • While a proven method to prevent Alzheimer's disease is not yet known, Dr. Azai says positive lifestyle changes to diet, exercise, and sleep can improve your overall brain health and that might reduce your risk for Alzheimer's disease.
  • If you know you have plaques and they're accumulating, but you don't have the symptoms yet, what would you do?
  • Well, that's when you want to get on it, right?
  • That's when you want to try different therapies or do simple, basic things we can all do.
  • Eat Better Mediterranean Diet has been shown to be beneficial.
  • Sleep is fundamental to human recovery.
  • Reduction of stress, reduction of alcohol, aerobic exercise, controlling your blood sugar.
  • management of weight and obesity, diabetes, hypertension, all these contribute to memory loss or memory difficulties over time.
  • So if we can optimize these, especially if you know that you may be at risk for Alzheimer's in the future, we can do the simple things that we can all do.
  • Diet, exercise, engaging with families and friends, new hobbies, has been shown to very significantly recover the brain.
  • The brain is very dynamic.