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The Worst Disease in Human History

Video vocabulary

coli

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US / 'kəʊlaɪ /

UK / 'koʊlaɪ /

A1
  • noun
  • Type of bacterium

just

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US / dʒʌst /

UK / dʒʌst /

A1
  • adjecitve
  • Proper or appropriate; as is deserved
  • Doing or being what is right or fair
  • Legally correct; having enough evidence
  • adverb
  • Almost; nearly
  • Exactly at the time of
  • Exactly (the same as, like)

stuff

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US / stʌf /

UK / stʌf /

A1
  • noun
  • Generic description for things, materials, objects
  • verb
  • To push material inside something, with force

those

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US / ðəʊz /

UK / ðoz /

A1
  • determiner
  • The people or things we are talking about
  • pronoun
  • The objects far from the speaker

aid

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US / eɪd /

UK / ed /

A2
  • noun
  • Action of giving help to others
  • Money or help given to those who need it
  • verb
  • To help others and provide things

black

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US / blæk /

UK / blæk /

A1
  • adjecitve
  • Color of the sky on a dark night
  • noun
  • A person with dark skin, often of African origin
  • Person's name
  • verb
  • To fill in something to make it a very dark color

head

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US / hed /

UK / hɛd /

A1
  • noun
  • Counter for the number of cattle
  • Natural mental ability or intelligence
  • Leader or person with the greatest authority
  • Mind; mental ability; mental state
  • Side of a coin with a head on it
  • Top part of your body with eyes and a mouth
  • Starting point of something, e.g. a river
  • verb
  • To hit a ball with your head in a game
  • To be first or at the front or top (e.g. a list)
  • To travel or move toward a particular place; To go in a particular direction
  • To become the leader of something
  • To lead or be responsible for something

for

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US / fə(r) /

UK / fɔr,fə /

A1
  • preposition
  • Used to show the purpose, or need of something

why

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US / waɪ /

UK / hwaɪ, waɪ /

A1
  • adverb
  • Question word to ask for a reason
  • exclamation
  • (Used to express surprise or approval)

time

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US / taɪm /

UK / taɪm /

A1
  • noun
  • Speed at which music is played; tempo
  • Point as shown on a clock, e.g. 3 p.m
  • Number of hours, minutes needed to do something
  • Occasion when something happens
  • Period or occasion that something occurred
  • Period in history or the past
  • Something measured in minutes, hours, days, etc.
  • How long an event takes; duration
  • verb
  • To check speed at which music is performed
  • To choose a specific moment to do something
  • To measure how long an event takes, e.g. a race
  • To schedule something to occur at a specific moment

through

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US / θru: /

UK / θru /

A2
  • adjecitve
  • having finished using or doing something
  • adverb
  • From the beginning of something until the end
  • preposition
  • Over, in, across an entire thing or place
  • Allowing you to pass between, or to
  • By a particular way or process; by the use of

difficult

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US / 'dɪfɪkəlt /

UK / ˈdɪfɪˌkʌlt, -kəlt /

A1
  • adjecitve
  • Hard; not easy; you need to work hard to do it

green

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US / gri:n /

UK / ɡrin /

A1
  • adjecitve
  • Color of young leaves
  • Covered with vegetation, e.g. grass
  • Concerned about protecting the environment
  • The color of young leaves
  • Lacking in experience/knowledge due to being young
  • Being not fully grown or ripe, as in fruit
  • noun
  • Large grassy area
  • used as a part of a name of a place (UK)

responsible

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US / rɪ'spɒnsəbl /

UK / rɪˈspɑnsəbəl /

A2
  • adjecitve
  • Being the cause of something that has occurred
  • Having the duty of dealing with something
  • Able to be trusted to do what needs to be done

title

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US / 'taɪtl /

UK / ˈtaɪtl /

A2
  • noun
  • Book produced by a publisher
  • Name given to something to identify or describe it
  • Name showing profession, marriage or social status
  • (Legal) the right to own something, e.g. property
  • Position of being the winner in a sport or contest
  • verb
  • To give a name to identify or describe something

definitely

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US / ˈdefɪnətli /

UK / ˈdefɪnətli /

A2
  • adverb
  • Without question; beyond doubt

kill

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US / kɪl /

UK / kɪl /

A1
  • noun
  • Animal killed by a person or other animal
  • verb
  • To cause someone to experience a lot of pain
  • To end the life of a person or other living thing
  • To be very funny
  • To prevent something from continuing or operating
  • To do something unimportant to pass time quickly

per

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US / pə(r) /

UK / pɚ /

A2
  • preposition
  • In the manner directed or suggested
  • For each; during each

replicate

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US / 'replɪkeɪt /

UK / ˈrɛplɪˌket /

A1
  • verb
  • To make one or more exact copies of itself
  • To repeat something (e.g. experiment, process)

sound

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US / saʊnd /

UK / saʊnd /

A1
  • adjecitve
  • Sensible, dependable and reliable
  • Unbroken or undisturbed, as of sleep
  • Firm or solid in structure
  • Sane; not mentally ill
  • Clearly reasoned; involving sense, good judgment
  • noun
  • Unique quality that characterizes a style of music
  • Waves traveling in air or water that can be heard
  • verb
  • To seem or appear to be, from what was said
  • To say in a clear deliberate manner
  • To make a noise, e.g. to ring a bell

evolve

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US / ɪ'vɒlv /

UK / ɪˈvɑlv /

B1
  • verb
  • To develop certain features
  • To develop or change slowly over time
  • To slowly change or develop into something better

individual

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US / ˌɪndɪˈvɪdʒuəl /

UK / ˌɪndəˈvɪdʒuəl /

A2
  • adjecitve
  • Made for use by one single person
  • Having a distinct manner different from others
  • noun
  • Single person, looked at separately from others

labor

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US / 'leɪbə(r) /

UK / ˈlebɚ /

A1
  • noun
  • The people with work in a community
  • All of the workers in a country, specific company
  • verb
  • To struggle to do something because it's difficult
  • To work hard (often physically) for many hours

much

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US / mʌtʃ /

UK / mʌtʃ /

A1
  • adjecitve
  • Very; to a high level or degree
  • adverb
  • A lot; large amount; a high degree of
  • Nearly; basically
  • On many occasions; often
  • noun
  • A large amount; a great quantity

strong

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US / strɒŋ /

UK / strɔŋ /

A1
  • adjecitve
  • (Of tea or beer) dark or thick
  • Having big muscles; physically powerful

ask

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US / ɑ:sk /

UK / æsk /

A1
  • verb
  • To say to someone that you want something

coincidence

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US / kəʊˈɪnsɪdəns /

UK / koʊˈɪnsɪdəns /

B1
  • noun
  • Occurrence by chance, not design or planned
  • State in which two ideas or opinions are the same

die

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US / daɪ /

UK / daɪ /

A1
  • noun
  • Cube with dots numbering 1-6 on it used in games
  • verb
  • To cease to function or work
  • (Of a thing) to stop being used or done
  • (Of a person) to stop living

everybody

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US / ˈevribɒdi /

UK / ˈɛvriˌbɑdi, -ˌbʌdi /

A1
  • pronoun
  • Every person; everyone

manufacture

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US / ˌmænjʊ'fæktʃə(r) /

UK / ˌmænjəˈfæktʃɚ /

A2
  • verb
  • To produce large numbers of products in a factory
  • To create a story or explanation that is not true

grow

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US / ɡrəʊ /

UK / ɡro /

A1
  • verb
  • To get bigger and more mature; make plants do this
  • To improve; to develop better skills over time
  • To develop and become bigger or taller over time

since

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US / sɪns /

UK / sɪns /

A1
  • adverb
  • At a point before the present time
  • conjunction
  • For this reason; because
  • preposition
  • From the time in the past that

specifically

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US / spəˈsɪfɪkli /

UK / spəˈsɪfɪkli /

A2
  • adverb
  • As regards a particular thing; closely related to
  • In particular

start

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US / stɑ:t /

UK / stɑrt /

A1
  • noun
  • First time or place that a thing exists; beginning
  • First opportunity to achieve something, e.g. a job
  • Sudden action or movement because you are scared
  • other
  • Beginning of something in place or time
  • verb
  • To do, be or happen for the first time; begin
  • To turn something on

test

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US / test /

UK / test /

A1
  • noun
  • A medical examination
  • Action to establish the truth or nature of
  • Examination; questions to measure knowledge
  • verb
  • To be given a medical examination
  • To try to establish the truth or nature of
  • To ask a series of questions to measure knowledge

set

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US / set /

UK / sɛt /

A1
  • adjecitve
  • Prepared for something; ready
  • noun
  • Complete group of something
  • Place where a television show or movie is filmed
  • Group of games in a tennis match
  • Device that receives radio or television signals
  • verb
  • To make a clock state or ring at a particular time
  • To decide upon or choose something
  • To make something ready for use (e.g. table)
  • To decide on a price for something
  • To become hard (of glue, concrete etc.)
  • To be located in a specific place or time
  • To put (e.g. a vase) down carefully in a place
  • To put someone in a certain condition or state
  • (Of the sun) to go lower than the horizon

well

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US / wel /

UK / wɛl /

A1
  • adjecitve
  • Being in a fortunate, good condition or state
  • Healthy and in good condition
  • adverb
  • In an acceptable, proper, or successful manner
  • In a complete, total, or full manner
  • A great and considerable degree
  • In a successful way, in a good or satisfactory way
  • exclamation
  • Used to begin or continue a particular statement
  • Used to show you want to start saying something
  • Used to express that you are waiting for a reply
  • You say this to change the topic of a conversation
  • Used to indicate you are making a final remark
  • noun
  • Long deep hole in the ground to get water
  • verb
  • To cause your eyes to fill with tears

resistance

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US / rɪ'zɪstəns /

UK / rɪˈzɪstəns /

A2
  • noun
  • Force that stops or slows movement of something
  • Refusal to accept something new or different

right

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US / raɪt /

UK / raɪt /

A1
  • adjecitve
  • Correct or true
  • The south side of you looking at the rising sun
  • adverb
  • Exactly in a place or time
  • Being appropriate for a particular event
  • In a straight or direct manner
  • noun
  • Something you are legally or morally allowed to do
  • Ideal of what is just and good
  • Political view based on conservatism
  • verb
  • To fix something previously wrong or unjust
  • To make upright, as a boat that has turned over

cell

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US / sel /

UK / sɛl /

A2
  • noun
  • Smallest unit of living things in biology
  • Group of people - often from a secret organization
  • Prisoner's room in a jail
  • Shortened form of 'cellphone'

example

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US / ɪgˈzɑ:mpl /

UK / ɪɡˈzæmpəl /

A1
  • noun
  • Thing, person which represents a category

fight

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US / faɪt /

UK / faɪt /

A1
  • noun
  • An argument or quarrel
  • Act of trying to hurt someone by hitting them
  • A struggle to do a difficult task
  • verb
  • To argue or quarrel with someone about something
  • To try to hurt someone by hitting them
  • To struggle to do a difficult task

happen

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US / 'hæpən /

UK / ˈhæpən /

A1
  • verb
  • To take place or occur

absolutely

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US / ˈæbsəlu:tli /

UK / ˈæbsəˌlutli, ˌæbsəˈlutli /

A2
  • adverb
  • Completely; totally; very

mean

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US / mi:n /

UK / min /

A1
  • adjecitve
  • Being good at
  • Nasty; unkind
  • Not liking to spend money; cheap; stingy
  • noun
  • Average of a set of numbers
  • verb
  • To express a particular idea or thought
  • To intend to do something in particular
  • To have a particular meaning or value

about

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US / ə'baʊt /

UK / əˈbaʊt /

A1
  • adverb
  • To be ready to; going to
  • Nearly; approximately; roughly
  • Near; next to; close to
  • In every direction; in the area of
  • preposition
  • Concerning or of (a topic)

different

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US / ˈdɪfrənt /

UK / ˈdɪfrənt /

A1
  • adjecitve
  • Not of the same kind; unlike other things

like

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US / laɪk /

UK / laɪk /

A1
  • adjecitve
  • Being equal in status or kind to something else
  • Similar; the same
  • adverb
  • For example
  • preposition
  • Used as a filler; used to ad emphasis
  • In a way similar to the way something is done
  • Such as; for example
  • verb
  • To want to
  • To find something pleasing; to prefer something

people

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US / 'pi:pl /

UK / ˈpipəl /

A1
  • noun
  • Persons sharing culture, country, background, etc.
  • Men, Women, Children

what

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US / wɒt /

UK / hwɑt, hwʌt, wɔt, wʌt,hwət, wət /

A1
  • pronoun
  • Thing or things that; the same kind as
  • Used to emphasize something you are about to say
  • adjecitve
  • Used to refer to a particular amount, or number
  • Used to place emphasis on a particular quality
  • adverb
  • To a certain degree
  • determiner
  • Question words used for asking for information
  • exclamation
  • Used to express excitement, shock, or surprise
  • Used to ask people to repeat something they said

that

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US / ðæt /

UK / ðæt, ðət /

A1
  • adjecitve
  • The person or thing being talked about
  • Used to identify something both the speakers know
  • adverb
  • Used to reinforce adjectives and adverbs
  • To such a degree
  • conjunction
  • Used to connect a noun clause
  • Used to introduce an adverbial clause
  • Used to introduce a noun clause
  • determiner
  • Used as a noun to refer to something
  • pronoun
  • Referring an object far away
  • Used to refer to the relative pronoun ‘which’

bunch

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US / bʌntʃ /

UK / bʌntʃ /

B1
  • noun
  • A group of things of the same kind
  • verb
  • To group people or things closely together
  • (Cloth) to gather/be gathered together in folds

hit

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US / hɪt /

UK / hɪt /

A1
  • noun
  • A planned killing, usually for money
  • Song, movie etc. that is successful
  • When someone strikes someone or something
  • Time when a player makes contact with the ball
  • Time when a website is accessed
  • verb
  • To have a negative impact on a person/place/thing
  • To press something, such as a button or switch
  • To suddenly realize the importance of something
  • To move your hand, a bat, etc. against with force
  • To fight, attack or damage something or someone
  • To arrive at a specific place, level, or goal
  • To make contact with the ball in a game or sport

tell

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US / tel /

UK / tɛl /

A1
  • verb
  • To (strongly) advise a person to do something
  • To be able to guess
  • To say or communicate information to someone
  • To inform, but without speaking; indicate
  • To have a negative effect on someone
  • To order someone to do something; command
  • To recognize something based on certain signs
  • To report something to an authority
  • To explain something or teach someone something

disable

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US / dɪs'eɪbl /

UK / dɪsˈebəl /

A2
  • verb
  • To cause something to be unable to act normally

bacteria

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US / bæk'tɪərɪə /

UK / bækˈtɪriə /

B2
  • noun
  • The very small creatures that can cause disease

first

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US / fɜ:st /

UK / fɚst /

A1
  • adjecitve
  • 1st; Coming before all others in time or place
  • noun
  • Something that has not happened before
  • Position of the winner of a competition

get

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US / ɡet /

UK / ɡɛt /

A1
  • verb
  • To become affected by illness or disease
  • To begin to feel or understand an emotion or idea
  • To send or bring someone or something home, etc.
  • To go somewhere to obtain something
  • To (cause to) do a particular thing
  • To obtain, receive or be given something
  • To currently have
  • To prepare for use
  • To understand something being said or read

hint

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US / hɪnt /

UK / hɪnt /

A2
  • noun
  • Helpful piece of information
  • Tiny quantity or sign of something
  • verb
  • To suggest without being direct about it

hard

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US / hɑ:d /

UK / hɑː(r)d /

A1
  • adjecitve
  • Difficult to do; difficult to understand
  • (Of facts) not able to be misunderstood; clear
  • (Of alcohol) strong
  • Involving or requiring lots of work, effort, care
  • Being full of pain, trouble, and problems
  • Strong
  • (Of edge) clear; sharp
  • Difficult to bend, break or cut; solid
  • adverb
  • With lots of force, power, or impact

obvious

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US / ˈɒbviəs /

UK / ˈɑbviəs /

A2
  • adjecitve
  • Easily understood and clear; plain to see

second

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US / 'sekənd /

UK / ˈsɛkənd /

A1
  • adjecitve
  • 2nd; the one following first
  • noun
  • Unit of time; one sixtieth of a minute
  • Short period of time that you wait for someone
  • (Do) soon
  • verb
  • To agree to support a proposal at a meeting

cause

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US / kɔ:z /

UK / kɔz /

A2
  • noun
  • Belief, goal or organization that people support
  • Reason for
  • verb
  • To make something happen; create effect or result

place

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US / pleɪs /

UK / ples /

A1
  • noun
  • Particular location, area or region
  • verb
  • To put someone in a particular type of situation
  • To put something in a certain location or position

sequence

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US / 'si:kwəns /

UK / ˈsikwəns, -ˌkwɛns /

A2
  • noun
  • Part of a movie showing one part of the story
  • verb
  • To arrange things in an order they should happen

down

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US / daʊn /

UK / daʊn /

A1
  • adjecitve
  • Being sad, sick, or unhappy
  • Not operating, working, or functioning as expected
  • adverb
  • In a sitting or lying position
  • Towards or on the ground, floor, or bottom
  • Written or copied onto a piece of paper or book
  • noun
  • A period of play in American Football
  • The soft, smooth hairs that cover a bird's body
  • preposition
  • Along something's path, course, or direction
  • Going from a higher position to a lower position
  • verb
  • To eat or drink very quickly and without stopping

malaria

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US / məˈleəriə /

UK / məˈlɛriə /

B2
  • noun
  • Disease caused by being bitten by a mosquito

slowly

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US / ˈsləʊli /

UK / ˈsloʊli /

A1
  • adverb
  • In an unhurried or not speedy manner

then

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US / ðen /

UK / ðɛn /

A1
  • adverb
  • A time that is not now
  • Following another thing in time or arrangement
  • Following on reasonably from what was just stated
  • At that time, not now

deadly

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US / ˈdedli /

UK / ˈdɛdli /

A2
  • adjecitve
  • Causing or capable of causing death
  • Being very accurate

into

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US / 'ɪntə /

UK / ˈɪntu /

A1
  • preposition
  • Moving or going inside something
  • In the same direction as; in the direction of
  • So as to become; taking the state of

love

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US / lʌv /

UK / lʌv /

A1
  • noun
  • Person's name
  • A very strong feeling of affection
  • The person you care very deeply about
  • Strong, deep emotional and sexual attraction
  • verb
  • To care for and like someone very strongly, deeply
  • To like doing very much; enjoy greatly
  • To feel a strong emotional and romantic attraction

john

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US / dʒɔn /

UK / dʒɑn /

A1
  • noun
  • A toilet.
  • A prostitute's client.
  • proper noun
  • (1165–1216), son of Henry II and Eleanor of Aquitaine; king of England 1199–1216; known as John Lack
  • The name of six kings of Portugal.

one

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US / wʌn /

UK / wʌn /

A1
  • pronoun
  • You; we; people in general; someone
  • The thing or person previously referred to
  • adjecitve
  • Used to refer to people generally
  • Being a strong example of (something mentioned)
  • number
  • Number 1

than

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US / ðən /

UK / ðən /

A1
  • conjunction
  • Used to compare two things that are not equal

body

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US / ˈbɒd.i /

UK / ˈbɑdi /

A1
  • noun
  • An object distinct from other objects
  • A group of people involved in an activity together
  • Main part of something
  • A person's physical self

make

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US / meɪk /

UK / mek /

A1
  • noun
  • Product made by a particular company; brand
  • verb
  • To arrange or prepare something e.g. dinner
  • To get to (a place) on time
  • To gain the status of (teacher, lawyer, etc.)
  • To create something by putting things together
  • To earn a certain amount of money at a job
  • To cause or force a person to do something
  • To cause something to happen or be formed

order

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US / 'ɔ:də(r) /

UK / ˈɔrdɚ /

A1
  • noun
  • Religious or social group, as of nuns
  • Instructions to others to do what you want
  • State in which things are neat and organized
  • What you ask to buy, e.g. food in restaurant
  • Social or political control of an area
  • verb
  • To put things in a sequence, e.g. a, b, c
  • To give instructions to others to do what you want
  • To ask for something you want to buy, e.g. a meal

ones

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US / wʌnz /

UK / wʌnz /

A1
  • number
  • Number 1, a single person or thing

run

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US / rʌn /

UK / rʌn /

A1
  • noun
  • Journey between two places made by ship or car
  • Series of similar things or successes and failures
  • Act of running; exercise of running
  • verb
  • To depart or travel according to a schedule
  • To cause an animal to move in a certain direction
  • (Of an engine) to be operating
  • To start or use a computer program
  • To flow in a certain direction, like a liquid
  • To manage or operate a business
  • To operate or drive something
  • (Of a road) to go from one place to another
  • To move your legs faster than walking

treat

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US / tri:t /

UK / trit /

A1
  • noun
  • Something you buy for others as a surprise present
  • something that tastes good and that is not eaten often
  • verb
  • To pay for the food or enjoyment of someone else
  • To use medical methods to try to cure an illness
  • To act in a certain way toward someone

bad

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US / bæd /

UK / bæd /

A1
  • adjecitve
  • Not good; wrong
  • Lacking in good morals; evil
  • No longer fresh; spoiled

immune

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US / ɪˈmju:n /

UK / ɪˈmjoon /

B1
  • adjecitve
  • Having a special protection from, e.g. the law

broad

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US / brɔ:d /

UK / brɔd /

A2
  • adjecitve
  • General; not detailed
  • Wide; from the shorter two sides to the other

less

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US / les /

UK / lɛs /

A1
  • adjecitve
  • Smaller in amount or degree
  • adverb
  • To a smaller degree
  • noun
  • A smaller amount
  • preposition
  • With the subtraction of

specific

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US / spəˈsɪfɪk /

UK / spɪˈsɪfɪk /

A2
  • adjecitve
  • Precise; particular; just about that thing
  • Concerning one particular thing or kind of thing

brief

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US / bri:f /

UK / brif /

A2
  • adjecitve
  • (Of period of time) short; using few words
  • noun
  • Information and instructions given for a meeting
  • verb
  • To give information/instructions before a meeting

genetic

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US / dʒəˈnetɪk /

UK / dʒəˈnɛtɪk /

B1
  • adjecitve
  • Of, relating to, or controlled by genes

big

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US / bɪɡ /

UK / bɪɡ /

A1
  • adjecitve
  • Popular
  • Serious
  • Large

little

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US / 'lɪtl /

UK / ˈlɪtl /

A1
  • adjecitve
  • Being short in length of time
  • Not great in size, amount, or degree; small
  • Being very young or younger than others
  • adverb
  • By an amount or degree that is not very much
  • Not often; rarely
  • noun
  • A person's name

let

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US / let /

UK / lɛt /

A1
  • verb
  • To allow someone to do something
  • Introducing a suggestion to do something together
  • To rent a house, etc. to others

might

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US / maɪt /

UK / maɪt /

A1
  • other
  • Used to politely request an action
  • Used to express that something could happen
  • Power, strength, force or influence

person

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US / 'pɜ:sn /

UK / 'pɜ:rsn /

A1
  • noun
  • Man, woman or child

spanish

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US / ˈspænɪʃ /

UK / ˈspænɪʃ /

A1
  • adjecitve
  • Concerning the culture and people of Spain

the

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US / ðə /

UK / ðə /

A1
  • article
  • Used to refer to something already mentioned
  • Used to show there is only one of something
  • determiner
  • Used to describe all of a family

wall

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US / wɔ:l /

UK / wɔl /

A1
  • noun
  • High, flat side of a room or building

also

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US / 'ɔ:lsəʊ /

UK / ˈɔlso /

A1
  • adverb
  • In addition; too; in a similar way

dish

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US / dɪʃ /

UK / dɪʃ /

A2
  • noun
  • Good-looking person of the opposite sex
  • Shallow container that you cook or serve food in
  • Food that has been prepared in a certain way

fine

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US / faɪn /

UK / faɪn /

A2
  • adjecitve
  • Good, acceptable or satisfactory
  • Of high quality; made with great skill
  • In a careful or exact manner; into small pieces
  • Being of high quality
  • Good; okay; no problem
  • (Of weather) good; not raining
  • noun
  • Money you have to pay because you broke a rule
  • verb
  • To pay money because you broke a law

kind

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US / kaɪnd /

UK / kaɪnd /

A1
  • adjecitve
  • In a caring and helpful manner
  • friendly and considerate
  • noun
  • One type of thing

live

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US / lɪv /

UK / liv /

A1
  • adjecitve
  • Being broadcast as events happen, not recorded
  • Carrying electric current; able to give a shock
  • Glowing because burning; hot
  • Not yet killed (for food)
  • adverb
  • (Music, drama) as it is performed
  • verb
  • To be alive
  • To experience a particular type of life
  • To make your home in a house or town

how

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US / haʊ /

UK / haʊ /

A1
  • adjecitve
  • To what degree? in what amount?
  • adverb
  • (Used to explain the way to do something)
  • exclamation
  • For what purpose or reason?
  • (Used to ask someone or something's condition)

year

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US / jə: /

UK / jɪr /

A1
  • noun
  • Unit of time equal to 12 months or 365 or 366 days
  • Used to refer to the age of a person

you

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US / jʊ /

UK / ju /

A1
  • pronoun
  • Person someone is speaking or writing to
  • Person or people in general

expose

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US / ɪk'spəʊz /

UK / ɪkˈspoʊz /

A2
  • noun
  • News article revealing secret information
  • verb
  • To make visible, without covering or protection
  • To allow light through a cameras lens onto film
  • To be talked about in the media
  • To make a secret known to the public
  • To experience something, often a harmful thing

petri

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US / ˈpetri /

UK / ˈpetri /

A1

this

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US / ðɪs /

UK / ðɪs /

A1
  • adjecitve
  • Used to indicate something already been discussed
  • Used to indicate something happening around now
  • adverb
  • An indication by a physical motion or gesture
  • A specific amount of
  • determiner
  • Person, thing, or idea near you
  • pronoun
  • Person, thing that has already been discussed

but

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US / bət /

UK / bʌt,bət /

A1
  • conjunction
  • Used before you say something different, opposite

give

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US / ɡɪv /

UK / ɡɪv /

A1
  • noun
  • Degree of flexibility in something, a material
  • verb
  • To hand over or present something to someone
  • To cause someone to have or experience something

good

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US / ɡʊd /

UK / ɡʊd /

A1
  • adjecitve
  • Proper, appropriate or right
  • (Of an amount) enough; plenty
  • Excellent; high quality
  • Acting well or properly; of moral character
  • In a positive or happy emotional state
  • noun
  • Advantage or benefit

really

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US / ˈri:əli /

UK / ˈriəˌli, ˈrili /

A1
  • adverb
  • Used to stress something that is said; definitely
  • In a true or accurate manner
  • Very

membrane

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US / 'membreɪn /

UK / ˈmɛmˌbren /

B2
  • noun
  • Outside covering of a cell
  • A thin covering of tissue or of a cell

would

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US / wʊd /

UK / wʊd /

A1
  • other
  • Used to indicate something imagined
  • Used to ask or request something politely
  • Verb used to indicate possibility, request etc.
  • Used to indicate a preference
  • Used to indicate a reaction
  • Indicates something that occurred repeatedly
  • Used to indicate willingness or ability to do

ally

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US / 'ælaɪ /

UK / 'ælaɪ /

B1
  • noun
  • Someone who supports, helps, or defends you
  • verb
  • To join a group to offer or receive support

disease

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US / dɪˈzi:z /

UK / dɪˈziz /

A2
  • noun
  • Illness that affects a person, animal, or plant

opportunity

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US / ˌɒpə'tju:nətɪ /

UK / ˌɑpɚˈtunɪti, -ˈtju- /

A2
  • noun
  • Time, situation when a thing might be done; chance

save

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US / seɪv /

UK / sev /

A1
  • noun
  • Preventing a player in a game from scoring a goal
  • preposition
  • Except; not including
  • verb
  • To make your computer keep a file
  • To keep for future use
  • To make something unnecessary; prevent
  • To keep money so that you will have it later
  • To keep something for future use, such as money
  • To keep or rescue someone or something from harm
  • To prevent a player in a game from scoring a goal
  • To avoid the unnecessary waste of energy, etc.

tuberculosis

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US / tju:ˌbɜ:kjuˈləʊsɪs /

UK / tu:ˌbɜ:rkjəˈloʊsɪs /

C2
  • noun
  • Disease affecting especially the lungs

book

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US / bʊk /

UK / bʊk /

A1
  • noun
  • Thing made of pages with writing on that you read
  • verb
  • (Police) to officially record someone's crimes
  • To reserve (hotel room, etc.) in advance
  • To produce a red or yellow card to a soccer player

safety

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US / ˈseɪfti /

UK / ˈsefti /

A1
  • noun
  • Device on a gun to prevent accidental shooting
  • State of being free from harm or danger

can

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US / kæn /

UK / kən,kæn /

A1
  • noun
  • A metal container for storing food
  • other
  • Able to; have the skill to; have the time to
  • verb
  • To have permission to
  • To be possible to do
  • To preserve food by sealing it in a metal container

whether

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US / ˈweðə(r) /

UK / ˈhwɛðɚ, ˈwɛð- /

A1
  • conjunction
  • If something will happen or not

surprising

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US / səˈpraɪzɪŋ /

UK / sərˈpraɪzɪŋ /

A1
  • adjecitve
  • Making you feel a bit shocked because unexpected
  • verb
  • To do something that another person didn't expect

now

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US / naʊ /

UK / naʊ /

A1
  • adverb
  • At the present time or moment
  • Right away or in the next possible moment
  • Used to refer to something that just happened
  • Time between the present and a moment in the past
  • conjunction
  • Resulting from or because of something

planet

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US / 'plænɪt /

UK / ˈplænɪt /

A2
  • noun
  • One of the bodies that orbit the sun

structure

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US / ˈstrʌk.tʃə /

UK / ˈstrʌk.tʃɚ /

A2
  • noun
  • The way in which the parts of a system or object are arranged or organized, or a system arranged in
  • verb
  • To plan, organize, or arrange the parts of something

not

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US / nɒt /

UK / nɑt /

A1
  • adverb
  • Word indicating the negative
  • (Used to form the negative of verbs)

pricing

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US / ˈpraɪsɪŋ /

UK / ˈpraɪsɪŋ /

A1
  • verb
  • To determine or set the cost of something

maybe

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US / ˈmeɪbi /

UK / ˈmebi /

A1
  • adverb
  • Possibly but not certainly; perhaps

size

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US / saɪz /

UK / saɪz /

A1
  • noun
  • How big or small a thing is
  • Standard measurements for clothing, shoes
  • verb
  • To make something to fit a particular measurement
  • To organize or group from small to large

hold

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US / həʊld /

UK / hold /

A1
  • noun
  • Section of a ship or plane used for storing things
  • Influence or power held over someone
  • Place of support for hands or feet when climbing
  • verb
  • To agree to keep something for someone
  • To have the capacity to support/contain something
  • To control an area and protect it from attack
  • To not allow someone to leave a place
  • To cause an event to happen at a place or time
  • To use hands or arms to carry or keep something
  • To have a specific quality or property
  • To keep an image, belief or feeling in your mind
  • To have or own something
  • To wait before being able to talk on the phone
  • To limit the movement of someone in a sport

space

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US / speɪs /

UK / spes /

A1
  • noun
  • Empty area kept for a specific reason, like a car
  • Empty area with nothing in it
  • Area in the sky where the stars are
  • Area between written words on a page
  • verb
  • To make a certain distance or time between

fat

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US / fæt /

UK / fæt /

A1
  • adjecitve
  • Having too much weight for the body size
  • Bringing or having a large amount of money
  • noun
  • Amount beyond what is usual or necessary
  • Oily part of meat

take

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US / teɪk /

UK / tek /

A1
  • noun
  • Filming of a single scene for TV or the movies
  • verb
  • To accept something that is offered
  • To use a method of traveling, e.g. a bus or train
  • To use a camera to make (a photo)
  • To pick up something and go away with it
  • To study a subject in school
  • To attempt to pass (an exam)
  • To require a certain amount of time, money, space

look

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US / lʊk /

UK / lʊk /

A1
  • noun
  • Person's beauty or physical attractiveness
  • Particular style of dress, clothes, or appearance
  • The way someone, something appears to be
  • Act of searching for or examining something
  • verb
  • To appear to be; seem

human

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US / 'hju:mən /

UK / ˈhjumən /

A1
  • adjecitve
  • Concerning or characteristic of people
  • noun
  • A person; a man, woman or child

largely

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US / ˈlɑ:dʒli /

UK / ˈlɑ:rdʒli /

A2
  • adverb
  • In large part; mainly or chiefly

very

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US / 'verɪ /

UK / ˈvɛri /

A1
  • adjecitve
  • Concerning a large degree or amount
  • adverb
  • A lot; much; many
  • Used to stress or emphasize a noun

they

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US / ðeɪ /

UK / ðe /

A1
  • pronoun
  • Two or more people, animals, or things

possible

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US / ˈpɒsəbl /

UK / ˈpɑsəbəl /

A1
  • adjecitve
  • Being able or appropriate for a task or purpose
  • Having a chance of happening, or being true

all

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US / ɔ:l /

UK / ɔl /

A1
  • adverb
  • Completely; totally
  • determiner
  • Being every one of something
  • pronoun
  • 100% of something; the complete amount

fast

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US / fɑ:st /

UK / fæst /

A1
  • adjecitve
  • In a way that is difficult to move or change
  • Moving or able to move quickly
  • Showing time that is later than the actual time
  • adverb
  • With a great deal of speed
  • noun
  • Period of time when a person chooses not to eat
  • verb
  • To refuse food for a long time

its

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US / ɪts /

UK / ɪts /

A1
  • adjecitve
  • Referring to or belonging to ‘it’
  • determiner
  • Of something; belonging or related to something
  • other
  • Possessive form of “it”

super

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US / ˈsu:pə(r) /

UK / ˈsupɚ /

A2
  • adjecitve
  • Of the highest quality; great; marvelous

who

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US / hu: /

UK / hu /

A1
  • pronoun
  • Which person
  • Used to introduce information about people

ago

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US / əˈgəʊ /

UK / əˈgoʊ /

A1
  • adverb
  • At a specified length of time in the past

contender

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US / kənˈtendə(r) /

UK / kənˈtɛndɚ /

B2
  • noun
  • Athlete or team competing (and likely) to win

death

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US / deθ /

UK / dɛθ /

A2
  • noun
  • When someone dies; the end of life

diagnose

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US / ˈdaɪəgnəʊz /

UK / ˌdaɪəgˈnoʊs /

B1
  • verb
  • To determine the cause of an illness or problem

figure

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US / ˈfiɡə /

UK / ˈfɪɡjɚ /

A1
  • noun
  • Your body shape
  • Numbers in a calculation
  • Doll-like thing meant to represent a person
  • Picture or diagram giving information in a text
  • Person who is very important or famous
  • Shape of a person seen indistinctly or in outline
  • Amount that is expressed in numbers
  • verb
  • To appear in a game, play or event
  • To calculate how much something will cost
  • To understand after thinking; work out

biofilm

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US / 'bɪɒfɪlm /

UK / 'bɪɒfɪlm /

A1
  • noun

their

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US / ðɛː /

UK / ðer /

A1
  • determiner
  • Belonging to them

symptom

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US / 'sɪmptəm /

UK / ˈsɪmtəm, ˈsɪmp- /

B1
  • noun
  • Sign that suggests that there is a problem

way

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US / weɪ /

UK / we /

A1
  • adverb
  • Used to emphasize the amount of something
  • noun
  • Particular aspect of something being thought about
  • One of various choices that could be made
  • Particular existing condition or state
  • (Often long) distance or length of time
  • How something is done
  • Route to go to a place
  • Small street
  • Usual behavior, emotions or habits of someone

old

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US / əʊld /

UK / old /

A1
  • adjecitve
  • Having existed for a long time, not young or new
  • Age of a person since birth

work

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US / wɜ:k /

UK / wɚk /

A1
  • adjecitve
  • Activity completed in order to make money
  • noun
  • The product of some artistic or literary endeavor
  • Everything created by an author, artist, musician
  • Activity you do in order to make money
  • Place of employment
  • Final product or result of a some labor or effort
  • verb
  • To bring into a specific state of success
  • To be functioning properly, e.g. a car
  • To do your job in your company or workplace
  • To make an effort to do something
  • To operate a machine or device

large

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US / lɑ:dʒ /

UK / lɑ:rdʒ /

A1
  • adjecitve
  • Big; of great size; broad, tall, wide, or fat

most

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US / məʊst /

UK / most /

A1
  • adverb
  • Very; extremely
  • Greatest possible degree
  • pronoun
  • Nearly all of something

pneumonia

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US / nju:ˈməʊniə /

UK / nu:ˈmoʊniə /

B2
  • noun
  • Serious illness affecting the lungs and breathing

secret

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US / 'si:krət /

UK / 'si:krət /

A1
  • adjecitve
  • That you don't want others to know; private
  • noun
  • Information you do not want others to know

two

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US / tu: /

UK / tu /

A1
  • number
  • 2

couple

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US / 'kʌpl /

UK / ˈkʌpəl /

A2
  • noun
  • Two people in a romantic relationship
  • Two of something; two people; a pair
  • verb
  • To join something to something else
  • (Two animals) to engage in sexual relations
  • To put two people or things together

rather

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US / 'rɑ:ðə(r) /

UK / ˈræðɚ, ˈrɑðɚ /

A1
  • adverb
  • Somewhat; fairly; not that much

flame

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US / fleɪm /

UK / flem /

A2
  • noun
  • The red part you can see in fire
  • verb
  • To glow
  • To burn or glow in a fire
  • To glow (as in the sun or sunset)
  • To send angry messages over the Internet; to troll

from

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US / frəm /

UK / frʌm, frɑm,frəm /

A1
  • preposition
  • Starting at a particular place, time or level

out

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US / aʊt /

UK / aʊt /

A1
  • adverb
  • No longer stylish (e.g. fashion)
  • Away from home, business, or the usual place
  • In a direction/movement away from inside or center
  • noun
  • Act when a batter cannot continue playing
  • verb
  • To tell people a secret

over

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US / 'əʊvə(r) /

UK / ˈovɚ /

A1
  • adverb
  • Finished; no longer happening
  • Towards the ground/away from a standing position
  • noun
  • A set of six consecutive balls bowled in cricket
  • other
  • Finished
  • preposition
  • Showing the relation when a thing is above another
  • On or covering something
  • Above or across something
  • More than you need
  • From one side to the other
  • In the direction of; toward

resource

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US / riˈsɔ:s /

UK / ˈriˌsɔrs, -ˌsors, -ˌzɔrs, -ˌzors, rɪˈsɔrs, -ˈsors, /

A2
  • noun
  • Something that can be used profitably; asset
  • An essential supply of something
  • Resourcefulness; ability to deal with problems
  • verb
  • To obtain (e.g. oil, gas) from its source

call

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US / kɔ:l /

UK / kɔl /

A1
  • noun
  • A order or request for action
  • The sound an animal makes, often when in danger
  • A correct prediction, e.g. a decision in a game
  • A short visit to a place or person
  • A decision by a referee or umpire in a game
  • verb
  • To make a request or order for action
  • (Animal) to make sounds to warn of danger
  • To announce the date of an election
  • To make a judgment about something
  • To give someone or something a name
  • To guess in advance the result or outcome
  • To visit a place or person for a short time
  • To phone someone
  • To speak, announce or shout in a loud voice

double

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US / 'dʌbl /

UK / ˈdʌbəl /

A2
  • adjecitve
  • Concerning or intended for use by two people
  • Two times the amount or degree; twice
  • Made of two parts that are the same, similar
  • noun
  • Person that is exactly like someone else
  • verb
  • To be used for two functions at the same time
  • To make or become twice as much

where

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US / hwɛə /

UK / hwɛr, wɛr /

A1
  • conjunction
  • At or in the place which
  • In whatever place
  • pronoun
  • Word you use to ask the location of something

help

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US / help /

UK / hɛlp /

A1
  • noun
  • Something given to enable a person to do something
  • Assistance given to someone in need
  • Someone who makes something easier or possible
  • verb
  • To act to enable a person to do something; assist
  • To make something better or less difficult

pathogen

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US / ˈpæθədʒən /

UK / ˈpæθədʒən /

C1
  • noun
  • Any disease-producing agent

think

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US / θɪŋk /

UK / θɪŋk /

A1
  • verb
  • To have an idea about something without certainty
  • To have an idea, opinion or belief about something

and

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US / ənd /

UK / ənd, ən,ænd /

A1
  • conjunction
  • Used to refer to two or more things
  • Plus; in addition; on top of that
  • Used to introduce an action that follows another

back

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US / bæk /

UK / bæk /

A1
  • adjecitve
  • Farthest from the front e.g. in a classroom
  • adverb
  • Have returned to a place you were before
  • noun
  • The part of a chair that the upper body leans upon
  • Location at the rear of something
  • The reverse of side something
  • Area on the rear of your body
  • verb
  • To bet money on something
  • To go backwards in a car
  • To support and encourage someone or some cause

lot

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US / lɒt /

UK / lɑt /

A1
  • noun
  • What happens to a person in life from chance; fate
  • A group of people seen together
  • Item for sale at an auction
  • Small area of land used for a purpose e.g. parking

strain

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US / streɪn /

UK / stren /

B2
  • noun
  • Injury to a muscle, leg etc. through overuse
  • Type or variation of a disease or bacillus
  • verb
  • To remove the water from (food) using a colander
  • To injure a muscle, leg etc. by using it too much

ton

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US / tʌn /

UK / tʌn /

A2
  • noun
  • Unit of weight; 907 kilograms (US); 1016 (UK)

could

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US / kəd /

UK / kʊd /

A1
  • other
  • Past form of 'can' to mean have ability
  • Used to ask for something politely, or to offer

know

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US / nəʊ /

UK / noʊ /

A1
  • verb
  • To be familiar with a person or place, thing
  • To feel sure or be convinced about something
  • To discover or be aware of something
  • To be able to distinguish
  • To have knowledge of things

slightly

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US / ˈslaɪtli /

UK / ˈslaɪtli /

B1
  • adverb
  • Only a little

spreadsheet

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US / ˈspredʃi:t /

UK / ˈsprɛdˌʃit /

C2
  • noun
  • Computer file for performing calculations

antibiotic

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US / ˌæntibaɪˈɒtɪk /

UK / ˌæntibaɪˈɑ:tɪk /

B1
  • adjecitve
  • (Drug) used to fight certain kinds of diseases
  • noun
  • Medicine that kills bacteria to fight infections

resistant

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US / rɪˈzɪstənt /

UK / rɪˈzɪstənt /

A2
  • adjecitve
  • Not affected by something
  • Being opposed to or wanting to prevent something

sample

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US / ˈsɑ:mpl /

UK / ˈsæmpl /

A2
  • noun
  • A small quantity of something used as a taster
  • verb
  • To try (e.g. food, drink), to see if you like it

model

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US / ˈmɒdl /

UK / ˈmɑ:dl /

A2
  • adjecitve
  • Being an excellent example of
  • noun
  • Person who wears fashion to show it to the public
  • A small scale copy of a full original
  • verb
  • To wear and display clothes at a fashion show
  • To make a small scale copy of a full original

world

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US / wɜ:ld /

UK / wɜrld /

A1
  • noun
  • All the humans, events, activities on the earth
  • Political division due to some kind of similarity

community

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US / kə'mju:nətɪ /

UK / kəˈmjunɪti /

A2
  • noun
  • Group of people who share a common idea or area

expert

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US / 'ekspɜ:t /

UK / ˈɛkˌspɚt /

A2
  • adjecitve
  • Having special knowledge or skill
  • noun
  • Skillful person with special knowledge

low

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US / ləʊ /

UK / lo /

A1
  • adjecitve
  • Having a small quantity, supply, or amount
  • Being unhappy or unpleasant in attitude
  • Not high; being near the ground, or bottom
  • (Of a voice, sound) being soft; quiet
  • noun
  • Situation of not having a lot of something

see

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US / si: /

UK / si /

A1
  • verb
  • To go on a date with someone
  • To predict whether something is, or will be true
  • To understand what someone says
  • To use your eyes to look at something
  • To visit a place often for sightseeing or pleasure
  • To visit or meet with someone
  • To find out by waiting or looking
  • To watch (a game, movie or TV show)

break

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US / breɪk /

UK / brek /

A1
  • noun
  • Time you stop an activity before continuing
  • End of a relationship
  • An escape from a place such as a jail
  • (Lucky) advantage or benefit from something
  • Find a solution or answer to a problem or crime
  • Change in the weather
  • verb
  • To create a new record e.g. running the 100m dash
  • To form a crack in something
  • To burst or become damaged
  • To end a relationship
  • To escape from a place such as a jail
  • To train a wild animal e.g. a horse
  • To separate into pieces by force, or by dropping
  • To act against a law, rule, or promise
  • To become known suddenly, as in the news
  • To not do what you promised e.g. not keep promises
  • To solve a crime, or answer a problem
  • To stop functioning properly
  • To suddenly start, open or commence
  • To change in pitch suddenly, as in a voice
  • To fall on the shore, as in waves
  • To begin or change suddenly; the dawn or weather
  • To defeat by causing the person to lose their will

infectious

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US / ɪnˈfekʃəs /

UK / ɪnˈfɛkʃəs /

A2
  • adjecitve
  • Capable of transmitting disease to others
  • Able to be spread easily
  • Making others feel like laughing

dangerous

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US / ˈdeɪndʒərəs /

UK / ˈdendʒərəs /

A1
  • adjecitve
  • Involving the chance of hurt or damage; risky

with

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US / wɪð /

UK / wɪð, wɪθ /

A1
  • preposition
  • As an employee of a certain company
  • Against something or someone
  • By using something as a means
  • Due to; because of
  • Including
  • Possessing as a feature
  • Related to
  • (Of the manner/attitude by which you do something)
  • Used to express that people or things are together

extra

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US / 'ekstrə /

UK / 'ekstrə /

A2
  • adjecitve
  • More than necessary; additional
  • noun
  • Items more than you need; additional items
  • Person who has a small part in a movie
  • Special version of a newspaper

have

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US / həv /

UK / hæv /

A1
  • verb
  • To drink, smoke, eat or use something
  • To experience the effects of something
  • To organize an event, or join in an activity
  • To own, possess, or hold something
  • To cause to happen or produce a particular effect

last

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US / lɑ:st /

UK / læst /

A1
  • adjecitve
  • Most recent; the latest
  • The one before
  • adverb
  • Final; with nothing following; after all others
  • Most recent; the latest
  • determiner
  • The one at the end
  • verb
  • To remain or continue for a certain period of time

machine

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US / mə'ʃi:n /

UK / məˈʃin /

A1
  • noun
  • Piece of equipment used to do work
  • Powerful group who control and organize things
  • verb
  • To shape, work on something, using a device

tuesday

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US / ˈtjuːzdeɪ /

UK / ˈtuːzdeɪ /

A1
  • noun
  • Second day of the week; the day after Monday

part

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US / pɑ:t /

UK / pɑ:rt /

A1
  • adjecitve
  • To some degree; half; not fully
  • noun
  • Division of a book
  • Ratio of something, e.g. 3 of gin, 1 of tonic
  • A line in a person's hair, made with a comb
  • Character an actor plays on stage, movie, or TV
  • Some, but not all of a specific thing
  • Role in causing something to happen
  • verb
  • To make a line in a person's hair, by using a comb
  • To move two things apart creating a space
  • To leave someone, or to break off a relationship

spit

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US / spɪt /

UK / spɪt /

B1
  • verb
  • To forcefully blow saliva out from your mouth

complicated

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US / 'kɒmplɪkeɪtɪd /

UK / ˈkɑmplɪˌketɪd /

B1
  • adjecitve
  • Difficult to do, understand or use
  • verb
  • To make more difficult to do, understand or use

flu

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US / flu: /

UK / flu /

B2
  • noun
  • Illness causing headache, fever etc.

weird

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US / wɪəd /

UK / wɪrd /

B1
  • adjecitve
  • Odd or unusual; surprising; strange

inside

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US / ˌɪn'saɪd /

UK / ɪnˈsaɪd, ˈɪnˌsaɪd /

A2
  • adjecitve
  • Being in something
  • Being in a building
  • adverb
  • Into a house; indoors
  • noun
  • Inner part or surface of something

once

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US / wʌns /

UK / wʌns /

A1
  • adverb
  • One time; one instance
  • At a time in the past
  • conjunction
  • When; as soon as

million

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US / ˈmɪljən /

UK / ˈmɪljən /

A1
  • number
  • 1,000,000

probably

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US / ˈprɒbəbli /

UK / ˈprɑbəbli /

A1
  • adverb
  • That is likely to happen or be true

while

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US / waɪl /

UK / hwaɪl, waɪl /

A1
  • conjunction
  • In spite of the fact that; although
  • During the time that; at the same time
  • noun
  • Short amount of time

actually

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US / ˈæktʃuəli /

UK / ˈæktʃuəli /

A1
  • adverb
  • Used to add new (often different) information

attack

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US / ə'tæk /

UK / əˈtæk /

A2
  • noun
  • Act intended to hurt someone physically, mentally
  • verb
  • To try to destroy, beat, or injure

compose

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US / kəmˈpəʊz /

UK / kəmˈpoʊz /

B1
  • verb
  • To calm yourself after being angry or upset
  • To write an essay, article, poem, music etc.
  • To form something from a series of parts
  • To come together to form or make e.g. music
  • To structure a picture or image to make an effect

cepheid

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US / 'kɪfaɪd /

UK / 'kɪfaɪd /

A1
  • noun

after

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US / 'ɑ:ftə(r) /

UK / ˈæftɚ /

A1
  • adverb
  • Later than another time, or behind something
  • conjunction
  • Following something before
  • preposition
  • When an event happened or time has passed

describe

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US / dɪ'skraɪb /

UK / dɪˈskraɪb /

A1
  • verb
  • To tell the appearance, sound, smell of something

guess

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US / ɡes /

UK / ɡɛs /

A1
  • noun
  • Answer given when you don't know if it is correct
  • verb
  • To give an answer without knowing if it is correct

many

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US / 'menɪ /

UK / ˈmɛni /

A1
  • determiner
  • Used to refer a large number of things

will

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US / wɪl /

UK / wɪl /

A1
  • noun
  • Desire or choice of someone
  • Document saying who gets your money when you die
  • Strong desire to do something; determination
  • Desire to do something; strong wish to do
  • other
  • Used with verbs to express the future
  • verb
  • To leave property to someone after your death
  • To use mental effort to make something happen
  • Am (is, are) likely to do
  • To influence someone to do something
  • To make something happen by strongly wanting it

thousand

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US / ˈθaʊznd /

UK / ˈθaʊzənd /

A1
  • number
  • Number 1,000

normal

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US / 'nɔ:ml /

UK / ˈnɔrməl /

A1
  • adjecitve
  • Standard or regular way of doing something
  • Having standard mental or physical ability, health

reason

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US / 'ri:zn /

UK / ˈrizən /

A1
  • noun
  • Ability to think about facts and form a judgment
  • Explanation for why something occurred or was done
  • verb
  • To think and make conclusions in a logical manner

day

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US / deɪ /

UK / de /

A1
  • noun
  • A period of 24 hours beginning at midnight
  • The period of time when it is light outside
  • Person's name

sure

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US / ʃʊə(r) /

UK / ʃʊr /

A1
  • adjecitve
  • Having no doubts about something
  • Have confidence in your own words or actions
  • Firmly established or held; being firm or stable
  • Being correct or true
  • adverb
  • What you say to agree willingly

colony

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US / 'kɒlənɪ /

UK / ˈkɑləni /

B2
  • noun
  • Group (bees, etc.) that live in the same place
  • Country/settlement controlled by another country

here

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US / hɪə(r) /

UK / hɪr /

A1
  • adverb
  • In this place; at this location, position or time

thick

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US / θɪk /

UK / θɪk /

A2
  • adjecitve
  • Difficult to see through, as fog
  • Full of (people, etc.)
  • (Of a liquid) that moves or pours slowly
  • Stupid; not smart
  • (Of person's accent) hard to understand
  • Having a large distance between two surfaces
  • Subtitles section
  • Good morning, John.
  • So if you asked me a couple of years ago what I thought the most deadly infectious disease in the world was, I probably would have started out with malaria, and then if you told me I was wrong after that,
  • I probably would have gone to AIDS, and then I would have needed a hint, you know?
  • I would have needed a hint to get to tuberculosis.
  • Which is weird, because it has been the most deadly infectious disease for like 99% of the last 10,000 years.
  • Like every once in a while, like Spanish flu or the Black Death, or for a very brief time there, COVID will overtake tuberculosis, but then tuberculosis will take its title back, as it has now.
  • It's actually a strong contender for the oldest infectious disease, so it's been with us for a long time, and I would love to like read a John Green book about it.
  • Like you are definitely the expert on this one.
  • Not long ago, I thought tuberculosis was like pneumonia, where it was like describing more symptoms, like a thing that happened to the body, rather than a specific disease, but no.
  • Tuberculosis is caused by a specific bacteria.
  • And there are a bunch of reasons why this bacteria is extra good at being bad, but one of the big ones is this.
  • This is the cell wall of the tuberculosis bacteria.
  • And if you think that that looks like a weird looking cell wall, you're right.
  • It's weird looking.
  • It's weirdly thick.
  • It is, in many different ways, the tuberculosis bacteria's secret weapon.
  • This big thick cell wall that's composed of largely like waxy fats makes it so much harder to fight tuberculosis, in so many different, weirdly different ways.
  • So first of all, you could guess maybe it's some of the obvious ways.
  • Like it's a big fat cell wall, so it's hard to get stuff through it into the cell, like antibiotics that might kill that cell.
  • But also, a lot of antibiotics work specifically by attacking the cell wall of bacteria, which is very different from the cell membranes of people.
  • So you can go after that specific weird thing about bacteria, and break it, and then the bacteria dies.
  • But, that works on normal cell walls.
  • So because the cell wall is so different, a lot of antibiotics just don't work as well on TB. And then there's some slightly less obvious ways that this cell wall helps out tuberculosis.
  • Like for example, we think that it makes it like easier for it to create biofilms, like really strong biofilms where lots of bacteria work together to create like structures that are broader than individual bacteria.
  • Biofilms make it harder for antibiotics to get in, and harder for immune cells to get in, allowing the tuberculosis to figure out how to like hold on for a really long time inside the body.
  • And also, having a bigger, weirder cell wall gives the tuberculosis bacteria more opportunities to evolve resistance to antibiotics.
  • There's just more places for resistance to evolve.
  • It's called cell wall remodeling, and TB is really good at it.
  • But then, there's like in my head the really surprising ways that this helps out tuberculosis.
  • Because this cell wall is so big and complicated, it's actually very difficult to manufacture.
  • Which means that tuberculosis grows really slowly, like it replicates much more slowly than most bacteria.
  • Which sounds like it would make it worse at being a pathogen, but no.
  • So first of all, a lot of antibiotics target fast replicating cells.
  • And tuberculosis just isn't a fast replicating cell, so those antibiotics are less good at attacking tuberculosis.
  • But second, and this is the really weird one, and it's just a flaming coincidence, We, in order to treat tuberculosis, have to figure out whether a person has tuberculosis, and if so, what kind they have,
  • And what antibiotics it might be resistant to.
  • And to do that, you have to take like the spit of a person and see what bacteria grows in a petri dish.
  • And this is easy for most bacteria, because the bacteria grows super fast.
  • Like a well-fed E. coli colony will double in size every 20 minutes.
  • For tuberculosis, that takes about a day.
  • In order to diagnose tuberculosis, you have to grow it in the petri dish.
  • And to see if it's resistant to antibiotics, you have to do that a bunch of different times, exposing it to a bunch of different antibiotics, which is just a lot of human labor.
  • Like it takes a lot of time, a lot of petri dishes, and a lot of space.
  • Which would be fine if like a thousand people a year got tuberculosis, but like 10 million people a year get tuberculosis.
  • But we have now sequenced a bunch of different TB strains, and we know the sequences that are responsible for antibiotic resistance.
  • And that allows us, with this machine, to run a sample through a little cartridge that will tell you if those genetic sequences are there.
  • That tells you two things.
  • One, that it's tuberculosis, and two, whether or not it's resistant to antibiotics.
  • That machine can do tons of different tests for tons of different diseases, and it does those tests all over the world.
  • But since TB is the world's most deadly infectious disease, and since it largely hits in communities that do not have a lot of resources, and because it kills millions of people per year and disables many more,
  • And has been doing that for many, many, many years, it is so, so, so important that we get the cost of these tests as low as possible.
  • Specifically for multidrug-resistant TB, which is just a very dangerous disease for everybody in the world.
  • In large part because of its weird cell wall, tuberculosis is just really good at evolving resistance to antibiotics.
  • To save lives, and for the safety of everybody on this planet, we need to get the cost of the tests down.
  • And I think that we can do that.
  • And by we, I mean all of us.
  • But I also mean the people at Danaher and Cepheid, who have worked hard on setting their pricing models, and who I'm sure have lots of targets they've been asked to hit.
  • But who absolutely can, I think, take a hard look at the spreadsheets, and ask, what's the right thing to do here?
  • And how can we get the cost of a multidrug-resistant TB cartridge down to like $5?
  • We are not enemies here, we are allies.
  • The enemy is tuberculosis.
  • So let's do it!
  • John, I'll see you on Tuesday.